HitPredict

Interactor 1: CNR1 (P21554)
Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)
Gene: CNR1

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11168387
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 472 Hs			1 354
+	Hs
		444665 CNR1_HUMAN (1-472): 1.31e-117: 354: 100.00		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		391327 CNR1_HUMAN (1-472): 1.31e-117: 354: 100.00		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		598724 S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		444664 S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		429011 ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		428884 ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		391305 ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		598719 S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		391347 OPRD_HUMAN (64-443): 1.38e-67: 222: 15.84		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		428911 ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77		GNAT2_HUMAN (1-354): 8.28e-172: 483: 69.49
+	Hs
		450984 OPRD_HUMAN (64-443): 1.38e-67: 222: 15.84		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		450979 OPRM_HUMAN (67-452): 1.36e-64: 215: 14.76		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		304718 S1PR2_HUMAN (85-414): 7.16e-72: 233: 26.21		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		598736 S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		686617 CCR1_HUMAN (118-442): 4.1e-64: 213: 15.52		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		580402 DRD5_HUMAN (133-421): 3.75e-68: 227: 19.82		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		602214 DRD5_HUMAN (133-421): 3.75e-68: 227: 19.82		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		686657 CCR1_HUMAN (118-442): 4.1e-64: 213: 15.52		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		429010 ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		602211 DRD5_HUMAN (133-421): 3.75e-68: 227: 19.82		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23