HitPredict

Interactor 1: TNAP3 (P21580)
Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]
Gene: TNFAIP3

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	8702721, 19615732, 18029035
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 790 Hs			1 246
+	Hs
		599644 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		599646 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		599616 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Mm
		1141361 TNAP3_MOUSE (1-790): 0: 1470: 88.10		1433B_MOUSE (1-246): 5.56e-141: 396: 98.78
+	Hs
		599643 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		599650 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		599622 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Mm
		905339 TNAP3_MOUSE (1-790): 0: 1470: 88.10		1433G_MOUSE (3-246): 1.91e-109: 317: 75.40
+	Hs
		683442 OTU7B_HUMAN (39-299): 1.32e-98: 326: 37.37		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		910126 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683790 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		927626 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		647359 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		647132 OTU7A_HUMAN (43-294): 2.76e-94: 316: 36.40		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		905220 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		904901 OTU7A_HUMAN (43-294): 2.76e-94: 316: 36.40		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		982591 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		982313 OTU7A_HUMAN (43-294): 2.76e-94: 316: 36.40		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		684378 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62