HitPredict

Interactor 1: TAF1 (P21675)
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
Gene: TAF1

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070577 - lysine-acetylated histone binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1893 Hs			1 726
+	Hs
		600081 TAF1_HUMAN (1-1893): 0: 2001: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		600253 TAF1_HUMAN (1-1893): 0: 2001: 100.00		BRPF3_HUMAN (37-484): 7.42e-31: 132: 14.82
+	Hs
		600110 TAF1_HUMAN (1-1893): 0: 2001: 100.00		BRPF1_HUMAN (20-274): 6.8e-26: 116: 14.94
+	Hs
		243928 TAF1_HUMAN (1-1893): 0: 2001: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		600197 TAF1_HUMAN (1-1893): 0: 2001: 100.00		PHIP_HUMAN (5-708): 5.37e-19: 94.5: 10.37
+	Hs
		600077 TAF1_HUMAN (1-1893): 0: 2001: 100.00		TAF1_HUMAN (23-303): 3.47e-17: 88.7: 13.52
+	Dm
		844325 TAF1_DROME (20-1878): 0: 1453: 45.26		Q9VC36_DROME (52-201): 9.78e-17: 87.2: 21.33
+	Sc
		805245 TAF1_YEAST (391-1229): 0: 662: 24.54		RSC2_YEAST (63-660): 6.42e-45: 175: 13.13
+	Sc
		805229 TAF1_YEAST (391-1229): 0: 662: 24.54		GCN5_YEAST (284-417): 7.13e-37: 145: 31.88
+	Sc
		805248 TAF1_YEAST (391-1229): 0: 662: 24.54		BDF2_YEAST (250-500): 3e-24: 110: 20.32
+	Sc
		728715 TAF1_YEAST (391-1229): 0: 662: 24.54		BDF1_YEAST (191-693): 8.87e-19: 93: 14.43
+	Sp
		999930 T111_SCHPO (501-1319): 0: 603: 26.01		YK82_SCHPO (29-148): 6.59e-30: 128: 33.61
+	Hs
		998609 EP300_HUMAN (957-1700): 2.05e-99: 359: 11.98		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Mm
		70941 EP300_MOUSE (957-1700): 9.41e-100: 360: 12.13		KAT2A_MOUSE (267-414): 7.42e-33: 137: 28.86
+	Mm
		70879 EP300_MOUSE (957-1700): 9.41e-100: 360: 12.13		F8VPR5_MOUSE (19-143): 9.58e-32: 135: 30.23
+	Mm
		70940 EP300_MOUSE (957-1700): 9.41e-100: 360: 12.13		KAT2B_MOUSE (267-414): 1.14e-31: 134: 28.19
+	Hs
		998943 EP300_HUMAN (957-1700): 2.05e-99: 359: 11.98		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Mm
		101467 F8VPR5_MOUSE (954-1707): 1.45e-90: 331: 12.52		KAT2B_MOUSE (267-414): 1.14e-31: 134: 28.19
+	Hs
		244347 EP300_HUMAN (957-1700): 2.05e-99: 359: 11.98		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56