HitPredict

Interactor 1: TFE2 (P21677)
Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Pancreas specific transcription factor 1c) (Transcription factor 3) (TCF-3) (Transcription regulator Pan)
Gene: Tcf3

Interactor 2: ID3 (P41138)
DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10567574
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression GO:0043425 - bHLH transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 649 Rn			1 119
+	Mm
		550183 TFE2_MOUSE (1-649): 0: 898: 95.08		ID3_MOUSE (1-119): 2.9e-61: 184: 99.16
+	Hs
		551503 TFE2_HUMAN (2-649): 0: 862: 80.00		ID3_HUMAN (1-119): 5.78e-63: 189: 97.48
+	Mm
		550178 TFE2_MOUSE (1-649): 0: 898: 95.08		ID1_MOUSE (3-100): 1.59e-42: 139: 46.60
+	Mm
		550184 TFE2_MOUSE (1-649): 0: 898: 95.08		ID2_MOUSE (1-118): 5.84e-43: 139: 37.68
+	Mm
		550218 TFE2_MOUSE (1-649): 0: 898: 95.08		Q6GTZ3_MOUSE (3-100): 2.19e-41: 135: 46.60
+	Hs
		551502 TFE2_HUMAN (2-649): 0: 862: 80.00		ID2_HUMAN (1-118): 1.73e-43: 140: 38.41
+	Hs
		551478 TFE2_HUMAN (2-649): 0: 862: 80.00		ID1_HUMAN (1-100): 4.91e-43: 139: 47.22
+	Hs
		551480 TFE2_HUMAN (2-649): 0: 862: 80.00		ID4_HUMAN (1-89): 3.07e-27: 99.8: 39.47
+	Hs
		971137 HTF4_HUMAN (1-649): 0: 732: 48.56		ID3_HUMAN (1-119): 5.78e-63: 189: 97.48
+	Mm
		780945 HTF4_MOUSE (1-649): 0: 729: 47.08		ID3_MOUSE (1-119): 2.9e-61: 184: 99.16
+	Mm
		780944 ITF2_MOUSE (2-649): 0: 718: 48.12		ID3_MOUSE (1-119): 2.9e-61: 184: 99.16
+	Hs
		970599 HTF4_HUMAN (1-649): 0: 732: 48.56		ID2_HUMAN (1-118): 1.73e-43: 140: 38.41
+	Hs
		780982 HTF4_HUMAN (1-649): 0: 732: 48.56		ID1_HUMAN (1-100): 4.91e-43: 139: 47.22
+	Mm
		781007 HTF4_MOUSE (1-649): 0: 729: 47.08		ID2_MOUSE (1-118): 5.84e-43: 139: 37.68
+	Mm
		1142448 HTF4_MOUSE (1-649): 0: 729: 47.08		Q6GTZ3_MOUSE (3-100): 2.19e-41: 135: 46.60
+	Mm
		781006 ITF2_MOUSE (2-649): 0: 718: 48.12		ID2_MOUSE (1-118): 5.84e-43: 139: 37.68
+	Mm
		1141284 ITF2_MOUSE (2-649): 0: 718: 48.12		Q6GTZ3_MOUSE (3-100): 2.19e-41: 135: 46.60
+	Hs
		551084 ITF2_HUMAN (2-649): 0: 712: 47.82		ID1_HUMAN (1-100): 4.91e-43: 139: 47.22
+	Hs
		814913 HTF4_HUMAN (1-649): 0: 732: 48.56		ID4_HUMAN (1-89): 3.07e-27: 99.8: 39.47
+	Hs
		551089 ITF2_HUMAN (2-649): 0: 712: 47.82		ID4_HUMAN (1-89): 3.07e-27: 99.8: 39.47