HitPredict

Interactor 1: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 156
+	Hs
		665376 EPHA3_HUMAN (22-975): 0: 1097: 43.01		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Hs
		665581 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		665591 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		665163 EPHA2_HUMAN (24-976): 0: 1056: 49.90		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Hs
		665164 EPHA2_HUMAN (24-976): 0: 1056: 49.90		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		872504 EPHA5_HUMAN (3-975): 0: 1117: 41.91		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		600663 EPHA1_HUMAN (1-976): 0: 1103: 100.00		TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00
+	Hs
		600539 EPHA1_HUMAN (1-976): 0: 1103: 100.00		DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02
+	Hs
		310035 EPHA1_HUMAN (1-976): 0: 1103: 100.00		TNKS1_HUMAN (49-142): 1.94e-13: 68.6: 25.26
+	Hs
		600670 EPHA1_HUMAN (1-976): 0: 1103: 100.00		TNKS2_HUMAN (8-136): 1.5e-11: 63.2: 21.05
+	Hs
		665439 EPHA3_HUMAN (22-975): 0: 1097: 43.01		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		665165 EPHA2_HUMAN (24-976): 0: 1056: 49.90		CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21
+	Hs
		665360 EPHA2_HUMAN (24-976): 0: 1056: 49.90		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		435574 IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		674564 UFO_HUMAN (274-964): 2.03e-146: 459: 23.29		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		983693 FAK1_HUMAN (630-884): 1.18e-63: 236: 45.88		ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59
+	Hs
		983635 FAK1_HUMAN (630-884): 1.18e-63: 236: 45.88		ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32