HitPredict

Interactor 1: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 217
+	Hs
		872422 EPHA5_HUMAN (3-975): 0: 1117: 41.91		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924590 EPHA7_HUMAN (2-975): 0: 1117: 43.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		872621 EPHB2_MOUSE (27-975): 0: 1113: 41.01		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		665574 EPHB2_HUMAN (27-975): 0: 1112: 41.01		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557643 EPHA5_HUMAN (3-975): 0: 1117: 41.91		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		789068 EPHA7_HUMAN (2-975): 0: 1117: 43.22		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337360 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		665558 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Mm
		337625 EPHA4_MOUSE (5-975): 0: 1110: 43.50		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Mm
		872619 EPHB2_MOUSE (27-975): 0: 1113: 41.01		ABL2_MOUSE (4-139): 1.55e-20: 91.3: 33.33
+	Hs
		412104 EPHA5_HUMAN (3-975): 0: 1117: 41.91		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		763386 EPHA4_MOUSE (5-975): 0: 1110: 43.50		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433772 EPHA7_HUMAN (2-975): 0: 1117: 43.22		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433265 EPHB2_HUMAN (27-975): 0: 1112: 41.01		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		412105 EPHA4_HUMAN (5-975): 0: 1108: 43.50		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		665608 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Mm
		403425 EPHB2_MOUSE (27-975): 0: 1113: 41.01		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522803 EPHB2_HUMAN (27-975): 0: 1112: 41.01		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433662 EPHA4_HUMAN (5-975): 0: 1108: 43.50		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522871 EPHA4_HUMAN (5-975): 0: 1108: 43.50		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58