HitPredict

Interactor 1: TA2R (P21731)
Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
Gene: TBXA2R

Interactor 2: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11504827
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 343 Hs			1 576
+	Hs
		428959 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		GRK6_HUMAN (1-576): 0: 573: 100.00
+	Hs
		621341 FSHR_HUMAN (12-338): 3.1e-57: 198: 16.06		GRK6_HUMAN (1-576): 0: 573: 100.00
+	Mm
		250677 OPSD_MOUSE (20-325): 2e-54: 183: 18.47		GRK6_MOUSE (1-576): 0: 566: 96.70
+	Hs
		428938 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76
+	Hs
		600868 TA2R_HUMAN (1-343): 3.98e-62: 203: 100.00		GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76
+	Hs
		428935 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		GRK4_HUMAN (1-575): 1.17e-168: 492: 65.34
+	Hs
		621339 FSHR_HUMAN (12-338): 3.1e-57: 198: 16.06		GRK4_HUMAN (1-575): 1.17e-168: 492: 65.34
+	Hs
		429053 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		GRK1_HUMAN (3-537): 1.99e-153: 453: 47.96
+	Hs
		428923 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59
+	Hs
		428943 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		ARBK2_HUMAN (2-545): 1.51e-143: 432: 36.04
+	Hs
		621336 FSHR_HUMAN (12-338): 3.1e-57: 198: 16.06		ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59
+	Bt
		362127 OPSD_BOVIN (3-325): 2.3e-54: 183: 18.13		GRK1_BOVIN (3-548): 2.11e-154: 455: 46.46
+	Hs
		622994 EDNRB_HUMAN (3-341): 3.76e-57: 193: 16.67		ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59
+	Hs
		726558 CXCR4_HUMAN (6-341): 2.18e-58: 193: 17.86		ARBK2_HUMAN (2-545): 1.51e-143: 432: 36.04
+	Hs
		621338 FSHR_HUMAN (12-338): 3.1e-57: 198: 16.06		AKT2_HUMAN (75-496): 7.73e-143: 423: 30.82
+	Hs
		568537 DRD1_HUMAN (41-340): 2.56e-57: 193: 13.10		KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85
+	Mm
		397200 ADRB1_MOUSE (41-323): 1.7e-56: 192: 14.15		KAPCA_MOUSE (144-500): 3.36e-143: 419: 28.57
+	Hs
		566320 PI2R_HUMAN (18-342): 3.37e-70: 225: 30.33		KPCA_HUMAN (176-496): 1.87e-58: 208: 38.08
+	Hs
		566282 TA2R_HUMAN (1-343): 3.98e-62: 203: 100.00		KPCA_HUMAN (176-496): 1.87e-58: 208: 38.08
+	Hs
		566281 DRD1_HUMAN (41-340): 2.56e-57: 193: 13.10		KPCA_HUMAN (176-496): 1.87e-58: 208: 38.08