HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 533
+	Hs
		601960 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		601934 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		601935 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		602002 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		601945 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		554266 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		1024132 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		383773 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		1070974 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		1070975 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		1071015 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		1070981 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		554307 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		383868 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		383899 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		383851 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Rn
		94037 Q9QX70_RAT (24-1145): 0: 1054: 43.41		F1LN91_RAT (103-512): 2.27e-33: 137: 12.39
+	Hs
		383853 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		383987 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		383583 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92