HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: TBB8 (Q3ZCM7)
Tubulin beta-8 chain (Tubulin beta 8 class VIII)
Gene: TUBB8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 444
+	Hs
		428019 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TBB5_HUMAN (1-429): 0: 720: 89.74
+	Hs
		383959 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TBB6_HUMAN (1-432): 0: 715: 86.81
+	Hs
		337782 EGFR_HUMAN (18-1157): 0: 1041: 42.30		TBB5_HUMAN (1-429): 0: 720: 89.74
+	Hs
		338266 EGFR_HUMAN (18-1157): 0: 1041: 42.30		TBB4B_HUMAN (1-427): 0: 719: 91.10
+	Hs
		338386 EGFR_HUMAN (18-1157): 0: 1041: 42.30		TBB3_HUMAN (1-442): 0: 719: 86.43
+	Hs
		337745 EGFR_HUMAN (18-1157): 0: 1041: 42.30		TBB4A_HUMAN (1-427): 0: 715: 90.16
+	Hs
		338407 EGFR_HUMAN (18-1157): 0: 1041: 42.30		TBB2A_HUMAN (1-430): 0: 715: 90.00
+	Hs
		338925 EGFR_HUMAN (18-1157): 0: 1041: 42.30		TBB6_HUMAN (1-432): 0: 715: 86.81
+	Hs
		435747 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		TBB6_HUMAN (1-432): 0: 715: 86.81
+	Hs
		428109 EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79		TBB5_HUMAN (1-429): 0: 720: 89.74
+	Hs
		872631 EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79		TBB4B_HUMAN (1-427): 0: 719: 91.10
+	Hs
		872702 EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79		TBB2B_HUMAN (1-430): 0: 719: 90.23
+	Hs
		381152 EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79		TBB4A_HUMAN (1-427): 0: 715: 90.16
+	Hs
		872701 EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79		TBB6_HUMAN (1-432): 0: 715: 86.81
+	Gg
		94429 KSYK_CHICK (715-958): 2e-43: 170: 36.80		TBB7_CHICK (1-429): 0: 720: 89.74
+	Hs
		411272 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		TBB5_HUMAN (1-429): 0: 720: 89.74
+	Hs
		537737 INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51		TBB3_HUMAN (1-442): 0: 719: 86.43