Protein: SOX6
Transcription factor SOX-6

Gene: SOX6
Organism: Homo sapiens
Interactions: 150
UniProt ID: P35712

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001217 - DNA-binding transcription repressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

776030

SOX5
Transcription factor SOX-5

2

17

High-throughput

0.811

High

776266

SOX13
Transcription factor SOX-13

2

18

High-throughput

0.789

High

764487

CTNB1
Catenin beta-1

1

20

Small-scale

0.724

High

776161

SOX2
Transcription factor SOX-2

1

18

High-throughput

0.691

High

776172

TFAM
Transcription factor A, mitochondrial

1

18

High-throughput

0.646

High

473825

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.634

High

776165

CTBP2
C-terminal-binding protein 2

2

13

Small-scale

0.620

High

576179

PO2F1
POU domain, class 2, transcription factor 1

1

20

High-throughput

0.618

High

776235

CIC
Protein capicua homolog

1

18

High-throughput

0.618

High

776255

HM20A
High mobility group protein 20A

1

20

High-throughput

0.618

High

776258

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

High-throughput

0.618

High

142871

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.601

High

776180

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.601

High

776170

UBC9
SUMO-conjugating enzyme UBC9

2

11

Small-scale

0.595

High

776196

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.595

High

776192

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

15

Small-scale

0.573

High

776188

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.561

High

540821

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.541

High

776236

ZN184
Zinc finger protein 184

1

1

High-throughput

0.541

High

776177

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

6

High-throughput

0.536

High

601581

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.515

High

184762

SHOX
Short stature homeobox protein

1

20

Small-scale

0.506

High

776238

CENPK
Centromere protein K

1

0

Small-scale

0.504

High

775802

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.501

High

135080

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

20

High-throughput

0.500

High

475281

RS17
Small ribosomal subunit protein eS17

1

3

High-throughput

0.500

High

766247

PHB1
Prohibitin 1

1

3

High-throughput

0.500

High

776162

PRC2A
Protein PRRC2A

1

20

High-throughput

0.500

High

776163

EMD
Emerin

1

3

High-throughput

0.500

High

776168

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.500

High

776169

RS11
Small ribosomal subunit protein uS17

1

4

High-throughput

0.500

High

776182

ILF2
Interleukin enhancer-binding factor 2

1

12

High-throughput

0.500

High

776184

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.500

High

776189

CIRBP
Cold-inducible RNA-binding protein

1

13

High-throughput

0.500

High

776191

CAPR1
Caprin-1

1

9

High-throughput

0.500

High

776193

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

15

High-throughput

0.500

High

776209

DHX30
ATP-dependent RNA helicase DHX30

1

13

High-throughput

0.500

High

776211

PABP2
Polyadenylate-binding protein 2

1

17

High-throughput

0.500

High

776219

CCAR2
Cell cycle and apoptosis regulator protein 2

1

7

High-throughput

0.500

High

776220

LS14A
Protein LSM14 homolog A

1

20

High-throughput

0.500

High

776228

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.500

High

776230

RBM33
RNA-binding protein 33

1

20

High-throughput

0.500

High

776241

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

20

High-throughput

0.500

High

776243

PDIP3
Polymerase delta-interacting protein 3

1

7

High-throughput

0.500

High

776244

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.500

High

776257

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

17

High-throughput

0.500

High

776274

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

5

High-throughput

0.489

High

776171

NOP14
Nucleolar protein 14

1

0

High-throughput

0.479

High

65707

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

4

High-throughput

0.479

High

67988

SOBP
Sine oculis-binding protein homolog

1

20

High-throughput

0.479

High

130707

TAF4
Transcription initiation factor TFIID subunit 4

1

13

Small-scale

0.479

High

174319

ZN609
Zinc finger protein 609

1

20

High-throughput

0.479

High

188192

HDAC3
Histone deacetylase 3

1

20

High-throughput

0.479

High

246454

KDM1A
Lysine-specific histone demethylase 1A

1

20

High-throughput

0.479

High

261376

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

20

High-throughput

0.479

High

277155

ZN217
Zinc finger protein 217

1

7

High-throughput

0.479

High

278256

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

297481

PIAS1
E3 SUMO-protein ligase PIAS1

1

12

High-throughput

0.479

High

505528

ATX1L
Ataxin-1-like

1

12

High-throughput

0.479

High

559733

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

693255

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

19

High-throughput

0.479

High

776160

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.479

High

776164

HIRA
Protein HIRA

1

20

High-throughput

0.479

High

776166

SUMO2
Small ubiquitin-related modifier 2

1

10

High-throughput

0.479

High

776167

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.479

High

776173

SATB1
DNA-binding protein SATB1

1

13

High-throughput

0.479

High

776174

MECOM
Histone-lysine N-methyltransferase MECOM

1

15

High-throughput

0.479

High

776175

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

776176

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

776178

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.479

High

776181

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

776183

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

776185

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.479

High

776186

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

5

High-throughput

0.479

High

776187

CTBP1
C-terminal-binding protein 1

1

13

High-throughput

0.479

High

776195

MEF2D
Myocyte-specific enhancer factor 2D

1

5

High-throughput

0.479

High

776197

NCOA2
Nuclear receptor coactivator 2

1

20

High-throughput

0.479

High

776198

ZFHX3
Zinc finger homeobox protein 3

1

20

High-throughput

0.479

High

776199

H31T
Histone H3.1t

1

20

High-throughput

0.479

High

776201

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

776202

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

11

High-throughput

0.479

High

776203

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

13

High-throughput

0.479

High

776204

TSH3
Teashirt homolog 3

1

19

High-throughput

0.479

High

776206

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

776208

UBN2
Ubinuclein-2

1

20

High-throughput

0.479

High

776210

I2BP2
Interferon regulatory factor 2-binding protein 2

1

20

High-throughput

0.479

High

776212

LDB1
LIM domain-binding protein 1

1

5

High-throughput

0.479

High

776213

ZFHX4
Zinc finger homeobox protein 4

1

20

High-throughput

0.479

High

776215

P66A
Transcriptional repressor p66-alpha

1

15

High-throughput

0.479

High

776216

I2BP1
Interferon regulatory factor 2-binding protein 1

1

9

High-throughput

0.479

High

776217

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

776221

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

20

High-throughput

0.479

High

776222

KDM2B
Lysine-specific demethylase 2B

1

8

High-throughput

0.479

High

776223

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

776224

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

4

High-throughput

0.479

High

776225

P66B
Transcriptional repressor p66-beta

1

15

High-throughput

0.479

High

776227

MAML1
Mastermind-like protein 1

1

20

High-throughput

0.479

High

776229

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

13

High-throughput

0.479

High

776231

ZN503
Zinc finger protein 503

1

3

High-throughput

0.479

High

776233

ZN521
Zinc finger protein 521

1

4

High-throughput

0.479

High

776234

NACC1
Nucleus accumbens-associated protein 1

1

20

High-throughput

0.479

High

776237

PYGO2
Pygopus homolog 2

1

3

High-throughput

0.479

High

776239

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

776240

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

776242

SSBP3
Single-stranded DNA-binding protein 3

1

19

High-throughput

0.479

High

776245

SP130
Histone deacetylase complex subunit SAP130

1

20

High-throughput

0.479

High

776246

ING2
Inhibitor of growth protein 2

1

20

High-throughput

0.479

High

776247

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

20

High-throughput

0.479

High

776248

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

776250

ZHX3
Zinc fingers and homeoboxes protein 3

1

20

High-throughput

0.479

High

776251

ZN703
Zinc finger protein 703

1

11

High-throughput

0.479

High

776253

PRD16
Histone-lysine N-methyltransferase PRDM16

1

14

High-throughput

0.479

High

776259

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

High-throughput

0.479

High

776260

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

776261

MBD2
Methyl-CpG-binding domain protein 2

1

10

High-throughput

0.479

High

776262

TCF20
Transcription factor 20

1

20

High-throughput

0.479

High

776263

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

776264

ING1
Inhibitor of growth protein 1

1

20

High-throughput

0.479

High

776265

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

776267

SATB2
DNA-binding protein SATB2

1

13

High-throughput

0.479

High

776268

ASF1A
Histone chaperone ASF1A

1

2

High-throughput

0.479

High

776269

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

8

High-throughput

0.479

High

776270

ZN281
Zinc finger protein 281

1

14

High-throughput

0.479

High

776275

RAI2
Retinoic acid-induced protein 2

1

1

High-throughput

0.479

High

776276

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

776277

NCOA3
Nuclear receptor coactivator 3

1

20

High-throughput

0.479

High

776278

ZHX2
Zinc fingers and homeoboxes protein 2

1

20

High-throughput

0.479

High

339139

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.458

High

238699

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

5

High-throughput

0.457

High

299089

FLOT1
Flotillin-1

1

7

High-throughput

0.457

High

776159

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.457

High

776179

LG3BP
Galectin-3-binding protein

1

10

High-throughput

0.457

High

776190

FLOT2
Flotillin-2

1

7

High-throughput

0.457

High

776232

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

High-throughput

0.457

High

776256

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

High-throughput

0.457

High

776271

RT23
Small ribosomal subunit protein mS23

1

2

High-throughput

0.457

High

776272

PRC2C
Protein PRRC2C

1

20

High-throughput

0.457

High

155549

NEMP1
Nuclear envelope integral membrane protein 1

1

1

High-throughput

0.437

High

776194

GSE1
Genetic suppressor element 1

1

4

High-throughput

0.437

High

776200

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

776207

CO039
Uncharacterized protein C15orf39

1

9

High-throughput

0.437

High

776214

PRSR1
Proline and serine-rich protein 1

1

20

High-throughput

0.437

High

776218

DHX40
Probable ATP-dependent RNA helicase DHX40

1

6

High-throughput

0.437

High

776249

CPVL
Probable serine carboxypeptidase CPVL

1

2

High-throughput

0.437

High

776252

FBRS
Probable fibrosin-1

1

4

High-throughput

0.437

High

776254

FBSL
Fibrosin-1-like protein

1

4

High-throughput

0.437

High

776273

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

5

High-throughput

0.437

High

776226

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.282

High

485848

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.261

Low

776205

RADX
RPA-related protein RADX

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025