HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31443721
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 903
+	Hs
		601981 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		1070998 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		601847 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1071010 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		338840 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		338959 EGFR_HUMAN (18-1157): 0: 1041: 42.30		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		808132 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		338861 EGFR_HUMAN (18-1157): 0: 1041: 42.30		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		338105 EGFR_HUMAN (18-1157): 0: 1041: 42.30		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		338634 EGFR_HUMAN (18-1157): 0: 1041: 42.30		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		383984 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Hs
		339005 EGFR_HUMAN (18-1157): 0: 1041: 42.30		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		338999 EGFR_HUMAN (18-1157): 0: 1041: 42.30		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Hs
		337535 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		339072 EGFR_HUMAN (18-1157): 0: 1041: 42.30		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Hs
		337392 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		434157 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		435577 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		337496 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Mm
		222826 ACK1_MOUSE (677-1328): 5.23e-124: 413: 21.75		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38