HitPredict

Interactor 1: DRD4 (P21917)
D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)
Gene: DRD4

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9843378
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 419 Hs			1 217
+	Hs
		723735 DRD3_HUMAN (33-417): 7.21e-75: 240: 36.86		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		686252 GASR_HUMAN (4-414): 3.28e-55: 190: 18.77		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Dm
		993225 MOODY_DROME (10-418): 9.1e-53: 188: 18.07		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Hs
		429008 ADRB2_HUMAN (332-418): 7.02e-28: 115: 35.63		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557605 DRD4_HUMAN (1-419): 6.55e-68: 223: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		557623 GASR_HUMAN (4-414): 3.28e-55: 190: 18.77		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337368 GASR_HUMAN (4-414): 3.28e-55: 190: 18.77		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412050 GASR_HUMAN (4-414): 3.28e-55: 190: 18.77		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433596 5HT2A_HUMAN (3-418): 2.86e-54: 188: 21.29		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		428898 ADRB2_HUMAN (332-418): 7.02e-28: 115: 35.63		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522740 ADRB3_HUMAN (49-411): 6.96e-22: 98.6: 32.17		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58