HitPredict

Interactor 1: DPOE (P21951)
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)
Gene: POL2

Interactor 2: MCM5 (P29496)
Minichromosome maintenance protein 5 (EC 3.6.4.12) (Cell division control protein 46)
Gene: MCM5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	25313033, 37730685
Identification Methods	biochemical, pull down
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0043596 - nuclear replication fork
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2222 Sc			1 775
+	Sc
		602323 DPOE_YEAST (1-2222): 0: 2941: 100.00		MCM4_YEAST (19-747): 0: 659: 28.05
+	Sc
		602364 DPOE_YEAST (1-2222): 0: 2941: 100.00		MCM6_YEAST (17-717): 0: 625: 26.09
+	Sp
		772834 DPOE_SCHPO (19-2220): 0: 2621: 46.14		MCM2_SCHPO (1-708): 0: 631: 31.02
+	Sc
		602321 DPOE_YEAST (1-2222): 0: 2941: 100.00		MCM2_YEAST (27-691): 7.37e-92: 308: 31.78
+	Sp
		252659 DPOE_SCHPO (19-2220): 0: 2621: 46.14		MCM7_SCHPO (67-695): 1.14e-96: 318: 35.42
+	Hs
		658320 DPOD1_HUMAN (1-637): 3.42e-144: 481: 14.67		MCM7_HUMAN (23-770): 0: 641: 28.11
+	Sc
		526828 DPOLA_YEAST (231-637): 1.77e-77: 287: 10.92		MCM5_YEAST (1-775): 0: 774: 100.00
+	Hs
		456102 DPOLA_HUMAN (89-635): 1.09e-97: 351: 12.42		MCM2_HUMAN (2-774): 0: 675: 27.72
+	Sc
		526829 DPOLA_YEAST (231-637): 1.77e-77: 287: 10.92		MCM4_YEAST (19-747): 0: 659: 28.05
+	Sc
		526827 DPOLA_YEAST (231-637): 1.77e-77: 287: 10.92		MCM2_YEAST (27-691): 7.37e-92: 308: 31.78