Interactor 1: BMP6 (P22004)
Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
Gene: BMP6

Interactor 2: RGMC (Q6ZVN8)
Hemojuvelin (Hemochromatosis type 2 protein) (Hemojuvelin BMP coreceptor) (RGM domain family member C)
Gene: HJV

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 19252486
Identification Methods anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RGM_C~TGF_beta, RGM_N~TGF_beta
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005615 - extracellular space
GO:0006879 - intracellular iron ion homeostasis
GO:0030509 - BMP signaling pathway
GO:0045944 - positive regulation of transcription by RNA polymerase II
and 2 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 513
Hs

1 426
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Ce

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Last updated: 15 Jul 2024