HitPredict

Interactor 1: PSB4 (P22141)
Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11)
Gene: PRE1

Interactor 2: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	11029046, 37968396, 15242647, 19446322, 20061387, 21878652
Identification Methods	coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Sc			1 993
+	Sc
		675415 PSB5_YEAST (2-197): 4.88e-65: 203: 22.45		RPN1_YEAST (1-993): 0: 1053: 100.00
+	Hs
		832095 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		656707 PSB5_HUMAN (2-197): 5.07e-66: 205: 20.92		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		1027764 PSB7_HUMAN (3-197): 4.25e-65: 203: 21.54		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		637679 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Sp
		953202 PSB4_SCHPO (1-193): 1.2e-80: 239: 53.89		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Sp
		195131 PSB1_SCHPO (3-191): 3.4e-67: 207: 23.28		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Dm
		1368690 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Dm
		1178970 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Hs
		832152 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Dm
		1359010 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSMD1_DROME (52-925): 0: 664: 13.63
+	Hs
		656760 PSB5_HUMAN (2-197): 5.07e-66: 205: 20.92		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		1303479 PSB7_HUMAN (3-197): 4.25e-65: 203: 21.54		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		637734 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		695 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Dm
		1178951 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSMD1_DROME (52-925): 0: 664: 13.63
+	Hs
		691 PSB5_HUMAN (2-197): 5.07e-66: 205: 20.92		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Hs
		710 PSB7_HUMAN (3-197): 4.25e-65: 203: 21.54		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Hs
		686 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		A0A087WW66_HUMAN (52-925): 0: 645: 13.34
+	Sc
		675399 PSB5_YEAST (2-197): 4.88e-65: 203: 22.45		RPN2_YEAST (52-815): 2.95e-177: 542: 15.54