Protein: AKT2
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)

Gene: AKT2
Organism: Homo sapiens
Interactions: 125
UniProt ID: P31751

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728629

DP13A
DCC-interacting protein 13-alpha

3

8

Small-scale

0.874

High

728603

SH3R1
E3 ubiquitin-protein ligase SH3RF1

3

10

Small-scale

0.872

High

728578

CDK3
Cyclin-dependent kinase 3

3

8

High-throughput

0.861

High

507093

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

14

High-throughput

0.811

High

728050

AKT1
RAC-alpha serine/threonine-protein kinase

2

17

High-throughput

0.802

High

728612

SNX27
Sorting nexin-27

2

20

High-throughput

0.793

High

250214

VINEX
Vinexin

2

10

High-throughput

0.783

High

728555

CDN1A
Cyclin-dependent kinase inhibitor 1

1

8

Small-scale

0.747

High

728594

PKHO1
Pleckstrin homology domain-containing family O member 1

1

2

Small-scale

0.747

High

728611

CLIP3
CAP-Gly domain-containing linker protein 3

1

8

Small-scale

0.747

High

349826

SNAI1
Zinc finger protein SNAI1

1

3

Small-scale

0.724

High

728556

VHL
von Hippel-Lindau disease tumor suppressor

1

6

Small-scale

0.724

High

728562

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.692

High

177805

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.691

High

728615

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

16

Small-scale

0.691

High

728618

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.691

High

728630

AKT3
RAC-gamma serine/threonine-protein kinase

1

17

High-throughput

0.691

High

728568

TCL1A
T-cell leukemia/lymphoma protein 1A

3

7

Small-scale

0.677

High

468111

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

663513

FSHR
Follicle-stimulating hormone receptor

1

5

Small-scale

0.665

High

728581

KPCZ
Protein kinase C zeta type

1

17

Small-scale

0.665

High

728620

ABCG8
ATP-binding cassette sub-family G member 8

1

0

High-throughput

0.663

High

728596

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

High-throughput

0.647

High

128390

PSMD9
26S proteasome non-ATPase regulatory subunit 9

3

0

High-throughput

0.638

High

665068

COT2
COUP transcription factor 2

2

14

High-throughput

0.628

High

728616

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

7

High-throughput

0.628

High

320212

SRBS2
Sorbin and SH3 domain-containing protein 2

1

10

High-throughput

0.621

High

193511

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

Small-scale

0.618

High

240867

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

247239

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

19

Small-scale

0.618

High

362845

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

375224

RASK
GTPase KRas

1

13

High-throughput

0.618

High

461191

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

463366

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

601185

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

629070

CCNA2
Cyclin-A2

1

3

Small-scale

0.618

High

728550

GRK5
G protein-coupled receptor kinase 5

1

16

High-throughput

0.618

High

728557

CCNF
Cyclin-F

1

9

High-throughput

0.618

High

728560

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.618

High

728569

DJB13
DnaJ homolog subfamily B member 13

1

13

High-throughput

0.618

High

728571

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

728584

SRSF5
Serine/arginine-rich splicing factor 5

1

11

High-throughput

0.618

High

728585

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

13

Small-scale

0.618

High

728589

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

728591

CDC37
Hsp90 co-chaperone Cdc37

1

18

Small-scale

0.618

High

728601

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

728602

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

16

Small-scale

0.618

High

728614

TRIB3
Tribbles homolog 3

1

16

Small-scale

0.618

High

728622

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

728623

WDR26
WD repeat-containing protein 26

1

9

Small-scale

0.618

High

728625

SEC12
Guanine nucleotide-exchange factor SEC12

1

11

High-throughput

0.618

High

728580

REL
Proto-oncogene c-Rel

2

16

High-throughput

0.606

High

728626

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

728576

PRKDC
DNA-dependent protein kinase catalytic subunit

2

20

Small-scale

0.602

High

728567

MTCP1
Protein p13 MTCP-1

2

7

Small-scale

0.586

High

395573

ESR1
Estrogen receptor

1

20

Small-scale

0.586

High

488412

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

6

Small-scale

0.578

High

728561

MAPK2
MAP kinase-activated protein kinase 2

1

15

Small-scale

0.575

High

728577

XIAP
E3 ubiquitin-protein ligase XIAP

1

2

Small-scale

0.575

High

728619

SIK2
Serine/threonine-protein kinase SIK2

1

14

Small-scale

0.575

High

728582

TISB
mRNA decay activator protein ZFP36L1

2

3

Small-scale

0.570

High

728588

PDK1
[Pyruvate dehydrogenase

2

6

Small-scale

0.552

High

728565

TTC3
E3 ubiquitin-protein ligase TTC3

1

7

Small-scale

0.543

High

728564

BIEA
Biliverdin reductase A

1

3

Small-scale

0.536

High

125826

AP4M1
AP-4 complex subunit mu-1

1

5

High-throughput

0.536

High

138909

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

10

High-throughput

0.536

High

219762

KCNQ3
Potassium voltage-gated channel subfamily KQT member 3

1

5

High-throughput

0.536

High

464120

TPM2
Tropomyosin beta chain

1

7

High-throughput

0.536

High

728570

DEST
Destrin

1

3

High-throughput

0.536

High

728600

XAF1
XIAP-associated factor 1

1

1

High-throughput

0.536

High

728607

FAT3
Protocadherin Fat 3

1

2

High-throughput

0.536

High

728627

PLPL3
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

1

0

High-throughput

0.518

High

225779

AP1G1
AP-1 complex subunit gamma-1

1

5

High-throughput

0.515

High

474504

VIME
Vimentin

1

12

Small-scale

0.515

High

728587

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

Small-scale

0.515

High

728605

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

13

High-throughput

0.515

High

728599

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.515

High

728583

LMAN2
Vesicular integral-membrane protein VIP36

1

0

High-throughput

0.513

High

728613

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.513

High

728628

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

1

0

High-throughput

0.513

High

245785

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

3

Small-scale

0.501

High

421579

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

728575

H31
Histone H3.1

1

14

Small-scale

0.501

High

728558

CASP3
Caspase-3

1

5

Small-scale

0.484

High

352622

TCL1B
T-cell leukemia/lymphoma protein 1B

1

7

Small-scale

0.481

High

387242

APOA1
Apolipoprotein A-I

1

2

High-throughput

0.481

High

728563

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

728598

STEA4
Metalloreductase STEAP4

1

2

High-throughput

0.481

High

449682

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.479

High

539122

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

4

High-throughput

0.479

High

540325

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

555346

SKI
Ski oncogene

1

1

Small-scale

0.479

High

588009

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

603853

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

659864

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.479

High

694721

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.479

High

728548

ARRB2
Beta-arrestin-2

1

5

Small-scale

0.479

High

728549

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

728552

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.479

High

728572

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

728573

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

Small-scale

0.479

High

728574

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

Small-scale

0.479

High

728579

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

Small-scale

0.479

High

728586

CUL1
Cullin-1

1

5

Small-scale

0.479

High

728593

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.479

High

728595

YIF1B
Protein YIF1B

1

1

High-throughput

0.479

High

728606

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.479

High

728617

EGLN1
Egl nine homolog 1

1

2

Small-scale

0.479

High

403135

APOB
Apolipoprotein B-100

1

0

High-throughput

0.460

High

728553

SPR2A
Small proline-rich protein 2A

1

0

High-throughput

0.460

High

728559

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.460

High

728590

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

High-throughput

0.460

High

728592

CCL14
C-C motif chemokine 14

1

0

High-throughput

0.460

High

728624

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.460

High

728554

COIL
Coilin

1

0

High-throughput

0.458

High

529186

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

728551

CTNB1
Catenin beta-1

1

6

Small-scale

0.445

High

728609

FUBP2
Far upstream element-binding protein 2

1

8

Small-scale

0.445

High

728631

MYO5A
Unconventional myosin-Va

1

5

Small-scale

0.445

High

728608

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

728597

OTUD1
OTU domain-containing protein 1

1

4

Small-scale

0.437

High

728604

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

728621

OFUT1
GDP-fucose protein O-fucosyltransferase 1

1

0

High-throughput

0.251

Low

728566

CMC4
Cx9C motif-containing protein 4

1

0

Small-scale

0.249

Low

728610

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025