HitPredict

Interactor 1: PSB4 (P22141)
Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11)
Gene: PRE1

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	11029046, 37968396, 15242647, 10848595, 29624167, 27302526, 19412159, 19446322, 21878652
Identification Methods	coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 198 Sc			1 338
+	Dm
		640788 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Sc
		675445 PSB5_YEAST (2-197): 4.88e-65: 203: 22.45		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Sc
		751185 PSB1_YEAST (3-192): 1e-57: 182: 22.63		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Sc
		625961 PSB2_YEAST (3-185): 5.08e-55: 177: 21.86		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Hs
		832073 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		640771 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		640794 Q9VUJ1_DROME (4-197): 1.8e-63: 199: 22.68		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		640767 PSA2_DROME (4-198): 2.91e-63: 197: 19.29		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		637651 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		638089 PSA4_HUMAN (3-198): 2.29e-62: 195: 18.72		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Sp
		784768 PSB4_SCHPO (1-193): 1.2e-80: 239: 53.89		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		1358671 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Sp
		195130 PSB1_SCHPO (3-191): 3.4e-67: 207: 23.28		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784781 PSA5_SCHPO (3-196): 7.67e-64: 199: 20.20		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		675389 PSB5_SCHPO (2-198): 2.32e-62: 196: 19.29		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784769 PSB2_SCHPO (3-196): 1.67e-62: 196: 23.20		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		1178949 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		1358675 Q9VUJ1_DROME (4-197): 1.8e-63: 199: 22.68		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		771306 PSA2_DROME (4-198): 2.91e-63: 197: 19.29		PSDE_DROME (3-264): 6.45e-48: 165: 16.90