HitPredict

Interactor 1: SEC22 (P22214)
Protein transport protein SEC22 (Suppressor of loss of YPT1 protein 2)
Gene: SEC22

Interactor 2: VAM3 (Q12241)
Syntaxin VAM3 (Vacuolar morphogenesis protein 3)
Gene: VAM3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.833

Property	Details
Experiments	24589832, 19591838, 22875988
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0006886 - intracellular protein transport GO:0006906 - vesicle fusion GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 214 Sc			1 283
+	At
		955702 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP22_ARATH (1-270): 5.42e-54: 178: 18.45
+	At
		812702 VA722_ARATH (1-197): 3.23e-82: 245: 16.42		SY121_ARATH (8-264): 5.31e-49: 167: 13.48
+	At
		1378372 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SY121_ARATH (8-264): 5.31e-49: 167: 13.48
+	Hs
		263179 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX2_HUMAN (18-281): 1.67e-53: 177: 12.08
+	At
		1352937 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SY122_ARATH (14-264): 2.76e-47: 162: 13.08
+	At
		1352985 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP42_ARATH (2-281): 1.83e-47: 162: 16.55
+	Mm
		139056 SC22B_MOUSE (1-211): 3.83e-76: 229: 35.65		STX1A_MOUSE (19-282): 3.95e-53: 176: 14.02
+	Hs
		263248 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX1A_HUMAN (19-282): 5.88e-53: 176: 14.02
+	At
		249598 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP41_ARATH (10-281): 2.54e-45: 157: 16.91
+	At
		1352876 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP43_ARATH (9-281): 4.03e-45: 156: 17.39
+	Hs
		263279 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX12_HUMAN (1-269): 9.8e-50: 167: 16.18
+	At
		955681 VA713_ARATH (1-210): 3.21e-69: 212: 16.11		SYP22_ARATH (1-270): 5.42e-54: 178: 18.45
+	Hs
		178331 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX7_HUMAN (16-281): 3.4e-47: 160: 21.72
+	Dm
		115805 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		STX1A_DROME (22-283): 1.42e-50: 169: 13.69
+	Hs
		263226 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX4_HUMAN (10-281): 1.22e-40: 144: 12.73
+	At
		812689 VA722_ARATH (1-197): 3.23e-82: 245: 16.42		SY111_ARATH (1-264): 1.09e-32: 123: 16.79
+	At
		1114744 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SY111_ARATH (1-264): 1.09e-32: 123: 16.79
+	Dm
		115838 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		Q9VR90_DROME (40-275): 5.28e-40: 144: 17.55
+	Dm
		115811 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		Q7K0X9_DROME (1-282): 2.34e-39: 140: 17.12
+	Sc
		605828 SEC22_YEAST (1-214): 6.14e-74: 224: 100.00		PEP12_YEAST (11-261): 7.81e-16: 77.6: 19.31