Protein: HPR1
THO complex subunit HPR1 (Hyperrecombination protein 1)

Gene: HPR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 105
UniProt ID: P17629

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000347 - THO complex
GO:0000445 - THO complex part of transcription export complex
GO:0000446 - nucleoplasmic THO complex
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

605914

THO2
THO complex subunit 2

17

0

Small-scale

0.936

High

605884

MFT1
THO complex subunit MFT1

15

0

Small-scale

0.934

High

150149

THP2
THO complex subunit THP2

13

0

Small-scale

0.929

High

605938

YRA1
RNA annealing protein YRA1

8

1

Small-scale

0.752

High

605873

GBP2
Serine/arginine

8

2

Small-scale

0.750

High

605931

SUB2
ATP-dependent RNA helicase SUB2

11

0

Small-scale

0.727

High

605917

TEX1
Protein TEX1

7

0

Small-scale

0.714

High

605941

MEX67
mRNA export factor MEX67

4

0

Small-scale

0.681

High

605886

NCBP1
Nuclear cap-binding protein complex subunit 1

4

0

Small-scale

0.648

High

605897

HRB1
Serine/arginine

4

1

Small-scale

0.636

High

605869

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.631

High

605934

NCBP2
Nuclear cap-binding protein subunit 2

3

0

Small-scale

0.613

High

594168

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

605893

PAF1
RNA polymerase II-associated protein 1

2

0

Small-scale

0.559

High

403341

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

0

Small-scale

0.547

High

605892

SWD3
COMPASS component SWD3

1

0

High-throughput

0.513

High

525855

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.504

High

543736

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.489

High

605928

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.486

High

401871

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

470453

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

605876

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

Small-scale

0.458

High

605879

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

605896

YHS7
Uncharacterized protein YHR127W

1

0

Small-scale

0.458

High

605904

MLP2
Protein MLP2

1

0

High-throughput

0.458

High

605905

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.458

High

605906

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.458

High

605925

CTK1
CTD kinase subunit alpha

1

0

Small-scale

0.458

High

605929

CDC73
Cell division control protein 73

1

0

Small-scale

0.458

High

605940

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

590175

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

1

High-throughput

0.437

High

605871

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

1

High-throughput

0.437

High

605881

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.437

High

392187

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.407

High

481468

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.407

High

510163

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

522981

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

578793

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

605882

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.407

High

605901

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

605902

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.407

High

605900

RSP5
E3 ubiquitin-protein ligase RSP5

2

0

Small-scale

0.323

High

605922

PRS8
26S proteasome regulatory subunit 8 homolog

2

0

Small-scale

0.310

High

605880

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

2

0

Small-scale

0.305

High

605889

CENPA
Histone H3-like centromeric protein CSE4

2

0

Small-scale

0.305

High

479961

PRTB
Cerevisin

1

0

High-throughput

0.279

Low

605912

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.279

Low

605915

SSK2
MAP kinase kinase kinase SSK2

1

0

High-throughput

0.279

Low

605923

IMA1
Importin subunit alpha

1

0

High-throughput

0.279

Low

605939

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.279

Low

605908

CYP7
Peptidyl-prolyl cis-trans isomerase CYP7

1

0

High-throughput

0.269

Low

605916

FPK1
Flippase kinase 1

1

0

High-throughput

0.269

Low

605932

ULS1
ATP-dependent helicase ULS1

1

0

High-throughput

0.269

Low

605888

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.265

Low

405018

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

486016

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.261

Low

591989

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.261

Low

605870

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

605920

ACT
Actin

1

0

High-throughput

0.261

Low

383499

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

409919

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433427

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

434798

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435752

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

441686

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

453009

CBP8
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

454852

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

504021

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512238

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512797

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514436

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

605872

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

605874

SRO9
RNA-binding protein SRO9

1

0

Small-scale

0.249

Low

605875

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

605878

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

605883

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

605885

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

605887

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

605890

YRA2
RNA annealing protein YRA2

1

0

Small-scale

0.249

Low

605891

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

605894

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

605895

SBE22
Protein SBE22

1

0

High-throughput

0.249

Low

605899

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

605907

GPI14
GPI mannosyltransferase 1

1

0

High-throughput

0.249

Low

605909

AIM24
Altered inheritance of mitochondria protein 24, mitochondrial

1

0

High-throughput

0.249

Low

605911

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

605913

RT27
Small ribosomal subunit protein mS33

1

0

High-throughput

0.249

Low

605919

YNO0
Uncharacterized protein YNL140C

1

0

High-throughput

0.249

Low

605921

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

605924

TR130
Trafficking protein particle complex II-specific subunit 130

1

0

High-throughput

0.249

Low

605926

SYF1
Pre-mRNA-splicing factor SYF1

1

0

Small-scale

0.249

Low

605927

RRP45
Exosome complex component RRP45

1

0

Small-scale

0.249

Low

605930

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

605933

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

605935

SWT1
Transcriptional protein SWT1

1

0

Small-scale

0.249

Low

605936

RRP6
Exosome complex exonuclease RRP6

1

0

Small-scale

0.249

Low

605937

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.249

Low

531590

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.232

Low

590521

HSP26
Heat shock protein 26

1

0

High-throughput

0.232

Low

605877

HS104
Heat shock protein 104

1

0

High-throughput

0.232

Low

605898

CAJ1
Protein CAJ1

1

0

High-throughput

0.232

Low

605903

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

605910

DPH4
Diphthamide biosynthesis protein 4

1

0

High-throughput

0.232

Low

605918

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025