HitPredict

Interactor 1: TRX1 (P22217)
Thioredoxin-1 (Thioredoxin I) (TR-I) (Thioredoxin-2)
Gene: TRX1

Interactor 2: TSA1 (P34760)
Peroxiredoxin TSA1 (Prx) (EC 1.11.1.24) (Cytoplasmic thiol peroxidase 1) (cTPx 1) (Protector protein) (PRP) (Thiol-specific antioxidant protein 1) (Thioredoxin peroxidase type Ia) (TPx type Ia) (Thioredoxin-dependent peroxide reductase) (Thioredoxin-dependent peroxiredoxin TSA1)
Gene: TSA1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	19801666, 30701970, 16272220, 37968396
Identification Methods	enzymatic study, biochemical, affinity chromatography technology, pull down
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045454 - cell redox homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 103 Sc			1 196
+	Hs
		495475 THIO_HUMAN (1-101): 1.14e-36: 121: 46.60		PRDX2_HUMAN (4-195): 1.42e-104: 300: 66.67
+	Mm
		956730 THIOM_MOUSE (5-101): 1.04e-32: 113: 36.00		PRDX2_MOUSE (4-195): 2.06e-104: 300: 65.63
+	Hs
		495510 THIO_HUMAN (1-101): 1.14e-36: 121: 46.60		PRDX1_HUMAN (4-193): 5.55e-100: 289: 59.69
+	Mm
		589514 THIOM_MOUSE (5-101): 1.04e-32: 113: 36.00		PRDX3_MOUSE (3-196): 8.31e-101: 293: 58.76
+	Hs
		685729 TXND5_HUMAN (7-101): 6.99e-27: 103: 26.73		PRDX2_HUMAN (4-195): 1.42e-104: 300: 66.67
+	Mm
		727682 THIOM_MOUSE (5-101): 1.04e-32: 113: 36.00		PRDX1_MOUSE (4-193): 2.14e-99: 287: 59.69
+	Mm
		139927 THIOM_MOUSE (5-101): 1.04e-32: 113: 36.00		PRDX4_MOUSE (4-195): 6.22e-98: 286: 55.73
+	Hs
		531737 PDIA4_HUMAN (3-103): 3.79e-25: 99.4: 22.02		PRDX3_HUMAN (2-196): 9.76e-103: 298: 58.46
+	Sc
		611720 TRX2_YEAST (1-102): 1.07e-37: 124: 78.64		TSA1_YEAST (1-196): 3.79e-93: 271: 100.00
+	Sc
		606220 TRX1_YEAST (1-103): 9.12e-42: 134: 100.00		TSA2_YEAST (1-195): 2.04e-88: 259: 86.15
+	Hs
		1026726 TXND5_HUMAN (7-101): 6.99e-27: 103: 26.73		PRDX4_HUMAN (4-195): 2.66e-97: 284: 55.21
+	Hs
		531815 PDIA4_HUMAN (3-103): 3.79e-25: 99.4: 22.02		PRDX4_HUMAN (4-195): 2.66e-97: 284: 55.21
+	Sc
		611752 TRX2_YEAST (1-102): 1.07e-37: 124: 78.64		TSA2_YEAST (1-195): 2.04e-88: 259: 86.15
+	Hs
		423216 PDIA1_HUMAN (3-101): 5.82e-25: 98.6: 23.59		PRDX4_HUMAN (4-195): 2.66e-97: 284: 55.21
+	Ss
		852832 THIO_SYNY3 (4-102): 6.1e-34: 114: 35.64		Y755_SYNY3 (3-196): 1.11e-91: 268: 46.15
+	So
		188731 TRXM_SPIOL (2-102): 1.56e-33: 115: 33.02		BAS1_SPIOL (3-194): 1.05e-88: 262: 50.78
+	Sc
		630634 TRX3_YEAST (2-101): 3.01e-36: 120: 46.00		PRX1_YEAST (3-196): 8.29e-70: 214: 28.16
+	Mm
		139705 THIOM_MOUSE (5-101): 1.04e-32: 113: 36.00		PRDX6_MOUSE (3-193): 1.02e-72: 220: 25.00
+	Ss
		852787 THIO_SYNY3 (4-102): 6.1e-34: 114: 35.64		P73348_SYNY3 (1-193): 1.12e-71: 217: 27.64
+	Dm
		1177773 THIO2_DROME (1-102): 4.01e-35: 117: 43.81		Q7JX87_DROME (3-193): 1.73e-68: 209: 29.90