Protein: HXK1
Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)

Gene: HXK1, HK1
Organism: Homo sapiens
Interactions: 164
UniProt ID: P19367

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0002720 - positive regulation of cytokine production involved in immune response
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

621481

HKDC1
Hexokinase HKDC1

5

14

High-throughput

0.919

High

621455

HXK2
Hexokinase-2

3

14

High-throughput

0.855

High

621456

HXK3
Hexokinase-3

3

14

High-throughput

0.855

High

621430

HXK1
Hexokinase-1

3

13

Small-scale

0.817

High

240715

PRKN
E3 ubiquitin-protein ligase parkin

5

5

Small-scale

0.702

High

621468

CAV1
Caveolin-1

3

2

High-throughput

0.662

High

621433

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

7

High-throughput

0.621

High

621444

SYUA
Alpha-synuclein

2

0

High-throughput

0.602

High

621517

ASPC1
Tether containing UBX domain for GLUT4

2

0

High-throughput

0.602

High

421472

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.577

High

621477

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

1

High-throughput

0.571

High

621550

MTCH2
Mitochondrial carrier homolog 2

2

4

High-throughput

0.571

High

348355

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

583448

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.554

High

621450

DNLI4
DNA ligase 4

1

1

High-throughput

0.552

High

479110

ENOG
Gamma-enolase

1

5

High-throughput

0.541

High

605542

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

High-throughput

0.536

High

621478

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

621510

PSKH2
Serine/threonine-protein kinase H2

1

2

High-throughput

0.536

High

621546

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

7

High-throughput

0.536

High

371130

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.521

High

621543

XPO7
Exportin-7

2

2

High-throughput

0.521

High

563165

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

276057

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.513

High

621451

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

621475

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

621514

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

621520

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

176142

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.493

High

557077

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.493

High

621467

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.493

High

621519

DYH6
Dynein axonemal heavy chain 6

1

0

High-throughput

0.493

High

621516

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

166859

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.479

High

177996

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

1

High-throughput

0.479

High

293180

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

345356

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

362748

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

375164

RASK
GTPase KRas

1

2

High-throughput

0.479

High

400255

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411331

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

536470

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

578375

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.479

High

580869

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

606199

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

612132

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

621435

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

621438

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

621439

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

621445

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

621447

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

621449

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

621454

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

621461

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

621462

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

621464

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

Small-scale

0.479

High

621469

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

621471

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

621476

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

621482

MIDN
Midnolin

1

1

High-throughput

0.479

High

621488

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

621495

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.479

High

621496

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.479

High

621498

ARL10
ADP-ribosylation factor-like protein 10

1

2

High-throughput

0.479

High

621500

FBF1
Fas-binding factor 1

1

2

High-throughput

0.479

High

621503

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

621507

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

621508

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

621529

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

621532

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

621535

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

5

High-throughput

0.479

High

621536

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

621539

MTCH1
Mitochondrial carrier homolog 1

1

4

High-throughput

0.479

High

621541

TES
Testin

1

1

High-throughput

0.479

High

621544

MAGD2
Melanoma-associated antigen D2

1

3

High-throughput

0.479

High

621547

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

621511

RSF1
Remodeling and spacing factor 1

1

1

High-throughput

0.470

High

105303

APRIO
Alternative prion protein

1

0

High-throughput

0.458

High

124225

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

125221

LEG9
Galectin-9

1

0

High-throughput

0.458

High

174924

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

184261

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

278808

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

281561

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

352948

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

488719

FURIN
Furin

1

0

High-throughput

0.458

High

610976

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

612857

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

621442

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

621443

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

621448

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

621452

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

621457

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

621459

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

621463

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

621466

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.458

High

621470

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

621472

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

621480

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.458

High

621484

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

621487

CDC73
Parafibromin

1

0

High-throughput

0.458

High

621492

CNTRL
Centriolin

1

0

High-throughput

0.458

High

621501

TITIN
Titin

1

0

High-throughput

0.458

High

621502

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

621505

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

621509

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.458

High

621512

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

621513

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

621525

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.458

High

621526

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

621528

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

621533

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.458

High

621537

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

621538

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

621548

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

529048

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

621483

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

621485

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

621518

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

621531

HELLS
Lymphoid-specific helicase

1

1

High-throughput

0.445

High

587886

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

621432

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.437

High

621436

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.437

High

621437

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

621441

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

621446

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.437

High

621453

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

621460

MAX
Protein max

1

2

High-throughput

0.437

High

621474

CUL4A
Cullin-4A

1

4

High-throughput

0.437

High

621490

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

621493

LRC49
Leucine-rich repeat-containing protein 49

1

1

High-throughput

0.437

High

621522

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

621545

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

621549

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.437

High

159501

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.426

High

322002

ENDD1
Endonuclease domain-containing 1 protein

1

0

High-throughput

0.426

High

621431

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

621440

SPB6
Serpin B6

1

0

High-throughput

0.426

High

621486

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

0

High-throughput

0.426

High

621504

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.426

High

621534

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.426

High

104103

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

621434

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

2

High-throughput

0.407

High

621489

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

621494

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.407

High

621499

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.407

High

621515

IFT27
Intraflagellar transport protein 27 homolog

1

1

High-throughput

0.407

High

621540

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.407

High

66923

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

621458

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

621465

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

621479

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

621491

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

621521

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

621527

ZFP14
Zinc finger protein 14 homolog

1

0

High-throughput

0.249

Low

621530

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

621506

SCMH1
Polycomb protein SCMH1

1

0

High-throughput

0.238

Low

621524

RETR1
Reticulophagy regulator 1

1

0

Small-scale

0.238

Low

477401

CD63
CD63 antigen

1

0

High-throughput

0.232

Low

621473

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.232

Low

621497

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

621523

REEP4
Receptor expression-enhancing protein 4

1

0

High-throughput

0.232

Low

621542

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025