HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	25527291, 27425610, 30097011, 31518855, 17597759
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 165
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (1-162): 5.98e-71: 212: 38.89
+	Hs
		607046 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2G1_HUMAN (4-164): 2.51e-69: 208: 50.00
+	Hs
		607023 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (1-162): 1.72e-67: 203: 38.89
+	Hs
		607099 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2R2_HUMAN (4-158): 9.21e-45: 149: 50.00
+	Oc
		1100193 UBA1_RABIT (1-1058): 0: 1356: 96.69		UB2R2_RABIT (4-158): 9.21e-45: 149: 50.00
+	Hs
		607022 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2R1_HUMAN (4-159): 1.54e-43: 145: 49.08
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (4-163): 5.27e-71: 212: 34.38
+	Sp
		116506 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC7_SCHPO (1-165): 4.56e-70: 210: 66.87
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (1-163): 4.52e-71: 212: 31.90
+	Sc
		608719 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC7_YEAST (1-165): 3.95e-70: 210: 62.42
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Sp
		293852 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC15_SCHPO (9-151): 3.2e-55: 173: 56.64
+	Hs
		48105 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2G2_HUMAN (1-165): 5.88e-71: 212: 100.00
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (1-162): 3.8e-36: 124: 37.65
+	Sc
		539443 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC3_YEAST (4-162): 3.31e-37: 130: 44.79
+	Sc
		410211 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (1-162): 1.08e-33: 118: 37.65