Protein: SYYM
Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)

Gene: SYYM, YARS2
Organism: Homo sapiens
Interactions: 220
UniProt ID: Q9Y2Z4

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0004831 - tyrosine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

162187

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

3

2

High-throughput

0.667

High

453720

ROA1
Heterogeneous nuclear ribonucleoprotein A1

3

2

High-throughput

0.667

High

745353

RBMX
RNA-binding motif protein, X chromosome

3

2

High-throughput

0.667

High

1348561

RM39
Large ribosomal subunit protein mL39

3

1

High-throughput

0.667

High

327612

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

4

0

High-throughput

0.664

High

1377488

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

3

Small-scale

0.647

High

1017472

CDC20
Cell division cycle protein 20 homolog

3

0

High-throughput

0.643

High

500235

CH60
60 kDa heat shock protein, mitochondrial

3

0

High-throughput

0.638

High

1153011

MRM1
rRNA methyltransferase 1, mitochondrial

3

0

High-throughput

0.638

High

1316597

RM04
Large ribosomal subunit protein uL4m

3

0

High-throughput

0.638

High

904197

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

1

High-throughput

0.628

High

958260

RBM3
RNA-binding protein 3

2

2

High-throughput

0.628

High

1047928

CIRBP
Cold-inducible RNA-binding protein

2

2

High-throughput

0.628

High

1158005

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

2

1

High-throughput

0.628

High

1348735

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

2

2

High-throughput

0.628

High

803284

IF2M
Translation initiation factor IF-2, mitochondrial

2

1

High-throughput

0.611

High

1282891

FAKD4
FAST kinase domain-containing protein 4

2

2

High-throughput

0.611

High

1331163

MTG2
Mitochondrial ribosome-associated GTPase 2

2

1

High-throughput

0.611

High

671136

ATPD
ATP synthase subunit delta, mitochondrial

2

0

High-throughput

0.602

High

856870

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

1345876

LYRM2
LYR motif-containing protein 2

2

0

High-throughput

0.602

High

1346050

DDX28
Probable ATP-dependent RNA helicase DDX28

2

0

High-throughput

0.602

High

1354361

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.602

High

307233

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

799412

EFTS
Elongation factor Ts, mitochondrial

2

0

High-throughput

0.585

High

1128298

SYAM
Alanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.585

High

229123

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

1152560

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

2

2

High-throughput

0.584

High

545188

PVR
Poliovirus receptor

1

0

High-throughput

0.578

High

59663

GTPBA
GTP-binding protein 10

1

1

High-throughput

0.536

High

157387

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

High-throughput

0.536

High

201724

MSI1H
RNA-binding protein Musashi homolog 1

1

2

High-throughput

0.536

High

271672

ERAL1
GTPase Era, mitochondrial

1

3

High-throughput

0.536

High

398313

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.536

High

513648

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.536

High

520770

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

620696

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

679519

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

3

High-throughput

0.536

High

793702

CACP
Carnitine O-acetyltransferase

1

1

High-throughput

0.536

High

1064988

SYLM
Leucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1073904

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

1

High-throughput

0.536

High

1116915

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

2

High-throughput

0.536

High

1131506

SYVM
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1153833

ACD10
Acyl-CoA dehydrogenase family member 10

1

1

High-throughput

0.536

High

1156335

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

2

High-throughput

0.536

High

1161628

SYDM
Aspartate--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1164732

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.536

High

1167692

RBMS3
RNA-binding motif, single-stranded-interacting protein 3

1

1

High-throughput

0.536

High

1184543

SYPM
Probable proline--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1185414

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.536

High

1232856

GUF1
Translation factor GUF1, mitochondrial

1

1

High-throughput

0.536

High

1282294

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.536

High

1282772

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

4

High-throughput

0.536

High

1286622

NSUN4
5-methylcytosine rRNA methyltransferase NSUN4

1

1

High-throughput

0.536

High

1286890

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.536

High

1286926

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

2

High-throughput

0.536

High

1294409

SYNM
Asparaginyl-tRNA synthetase

1

1

High-throughput

0.536

High

1301187

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.536

High

1301302

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

1312102

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

1314550

SYTM
Threonine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1334397

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1334677

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

1

High-throughput

0.536

High

1345562

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1356687

SARDH
Sarcosine dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1356819

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

1

High-throughput

0.536

High

47901

RBM47
RNA-binding protein 47

1

0

High-throughput

0.513

High

59359

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.513

High

63497

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.513

High

127611

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

128349

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.513

High

167302

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

181273

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

241390

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.513

High

254770

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

258560

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.513

High

276762

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

0

High-throughput

0.513

High

282171

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

1

0

High-throughput

0.513

High

300861

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

High-throughput

0.513

High

398423

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

506851

SPTB1
Spectrin beta chain, erythrocytic

1

0

High-throughput

0.513

High

587079

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

602990

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.513

High

612078

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.513

High

642873

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

646478

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

670566

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

790289

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

813865

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

815465

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

847168

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

0

High-throughput

0.513

High

867384

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

873503

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.513

High

945396

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

952186

SRSF3
Serine/arginine-rich splicing factor 3

1

0

High-throughput

0.513

High

962474

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

1042888

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1051147

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1052188

MAP7
Ensconsin

1

0

High-throughput

0.513

High

1116997

PPCEL
Prolyl endopeptidase-like

1

0

High-throughput

0.513

High

1118244

RM51
Large ribosomal subunit protein mL51

1

0

High-throughput

0.513

High

1126934

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.513

High

1132581

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1133985

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.513

High

1136106

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.513

High

1159959

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1188483

GLUCM
D-glutamate cyclase, mitochondrial

1

0

High-throughput

0.513

High

1192942

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.513

High

1198812

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.513

High

1200806

NT5D3
5'-nucleotidase domain-containing protein 3

1

0

High-throughput

0.513

High

1202201

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1217833

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

0

High-throughput

0.513

High

1219135

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1222953

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.513

High

1232990

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1234840

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

1235051

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1245011

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

0

High-throughput

0.513

High

1251211

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.513

High

1253439

RM30
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.513

High

1253787

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

1287860

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

1288515

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.513

High

1289184

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.513

High

1289727

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1294397

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.513

High

1302637

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.513

High

1306471

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

1310589

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

1

0

High-throughput

0.513

High

1312793

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1315841

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.513

High

1316482

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.513

High

1318434

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1328020

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1342499

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

1342694

NGRN
Neugrin

1

0

High-throughput

0.513

High

1345989

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1346413

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.513

High

1346595

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

1346847

RT18A
Large ribosomal subunit protein mL66

1

0

High-throughput

0.513

High

1346915

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

1347671

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.513

High

1348999

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

1355501

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1355717

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1356749

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1377340

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.513

High

1377403

YBOX2
Y-box-binding protein 2

1

0

High-throughput

0.513

High

1377486

MTO1
Protein MTO1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1377489

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

974527

ENL
Protein ENL

1

0

High-throughput

0.493

High

215774

GTPB6
Putative GTP-binding protein 6

1

3

High-throughput

0.489

High

476606

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

120727

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.479

High

272775

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

440821

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

894611

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

901070

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

951480

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1018130

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

1064871

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1068126

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1256782

FBF1
Fas-binding factor 1

1

1

High-throughput

0.479

High

1335411

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.479

High

149450

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

263034

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

295432

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

360563

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

442610

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

473429

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

486683

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

504994

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

554112

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

718344

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.458

High

777796

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

790084

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

868817

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

970085

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

981490

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1020617

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1036229

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1045905

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1086864

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1161975

FIGL1
Fidgetin-like protein 1

1

0

High-throughput

0.458

High

1192543

CNTRL
Centriolin

1

0

High-throughput

0.458

High

1289036

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1313280

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1314245

TR61B
tRNA

1

0

High-throughput

0.458

High

1333140

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1343827

ANLN
Anillin

1

0

High-throughput

0.458

High

1346525

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

70225

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

2

High-throughput

0.445

High

1284330

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

2

High-throughput

0.445

High

1076827

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.437

High

402656

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1130748

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

89998

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

1221506

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

0

High-throughput

0.347

High

1149647

Z324B
Zinc finger protein 324B

2

0

High-throughput

0.328

High

1168216

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

1164291

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.316

High

1224925

FAM9B
Protein FAM9B

1

0

High-throughput

0.299

High

490082

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

0

High-throughput

0.279

Low

838600

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

993137

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

1242893

CHDH
Choline dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1344740

D39U1
Epimerase family protein SDR39U1

1

0

High-throughput

0.279

Low

1355460

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

1173838

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

0

High-throughput

0.269

Low

101305

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

348301

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

652670

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721840

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1172364

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1189080

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1198714

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.249

Low

1271859

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

1331686

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1357431

LORF1
LINE-1 retrotransposable element ORF1 protein

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024