HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2G1 (P62253)
Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]
Gene: UBE2G1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	30279270, 30097011, 17597759
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 170
+	Hs
		607099 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2R2_HUMAN (1-163): 6.15e-72: 218: 54.27
+	Hs
		607022 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2R1_HUMAN (1-163): 6.6e-70: 213: 51.83
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (5-165): 1.53e-71: 213: 34.16
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (5-165): 3.29e-69: 208: 32.92
+	Oc
		1100193 UBA1_RABIT (1-1058): 0: 1356: 96.69		UB2R2_RABIT (1-163): 8.43e-68: 207: 54.27
+	Hs
		607038 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2G2_HUMAN (1-164): 3.03e-66: 201: 50.00
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (5-165): 1.58e-70: 211: 35.40
+	Sp
		116506 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC7_SCHPO (1-163): 1.34e-69: 209: 49.69
+	Sp
		293852 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC15_SCHPO (1-151): 8.11e-66: 200: 66.89
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (4-165): 4.48e-70: 210: 33.33
+	Sc
		608719 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC7_YEAST (3-164): 3.65e-66: 200: 49.38
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (5-165): 3.29e-69: 208: 32.92
+	Hs
		48105 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2G2_HUMAN (1-164): 3.03e-66: 201: 50.00
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (10-167): 1.37e-31: 112: 38.61
+	Sc
		539443 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC3_YEAST (9-166): 7.29e-36: 127: 41.62
+	Sc
		854609 UBA2_YEAST (61-448): 8.38e-85: 289: 15.49		UBC7_YEAST (3-164): 3.65e-66: 200: 49.38