HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	38113892, 27425610, 30097011, 17597759
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 183
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33
+	Hs
		607023 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (4-150): 8.87e-65: 197: 30.46
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (4-149): 8e-64: 195: 30.67
+	Dm
		715098 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		UBE2N_DROME (5-152): 6.43e-62: 190: 34.21
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (7-149): 2.5e-70: 211: 29.25
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (1-149): 7.24e-71: 212: 32.03
+	Sp
		293850 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC8_SCHPO (1-178): 2.41e-62: 192: 55.31
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		782203 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Sp
		251976 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC1_SCHPO (38-153): 1.48e-24: 97.1: 36.21
+	Sc
		600919 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC1_YEAST (38-153): 1.18e-22: 92: 37.93
+	Sc
		608714 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC13_YEAST (31-152): 1.47e-22: 90.1: 37.71