HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 8576257, 19250909, 11807090, 25527291, 28924046, 29263404, 27425610, 30279270, 30097011, 30246024, 30587574, 27182664, 35271311, 36114200, 34518685, 36563856, 36660824, 36758106, 22069333, 22350887 and 3 others

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Identification Methods enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1058
Hs

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Last updated: 15 Jul 2024