Protein: CSN4
COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)

Gene: CSN4, COPS4
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q9BT78

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1272541

CSN6
COP9 signalosome complex subunit 6

16

12

Small-scale

0.986

High

1370339

CSN5
COP9 signalosome complex subunit 5

15

15

Small-scale

0.984

High

1413217

CSN3
COP9 signalosome complex subunit 3

11

18

Small-scale

0.976

High

958704

CSN2
COP9 signalosome complex subunit 2

11

20

Small-scale

0.974

High

1115391

CUL4B
Cullin-4B

10

12

Small-scale

0.973

High

1406119

CSN8
COP9 signalosome complex subunit 8

8

2

Small-scale

0.968

High

1114156

CUL3
Cullin-3

8

12

Small-scale

0.966

High

1094405

CSN1
COP9 signalosome complex subunit 1

7

20

Small-scale

0.956

High

1413213

CSN7A
COP9 signalosome complex subunit 7a

6

9

Small-scale

0.947

High

1413200

CSN7B
COP9 signalosome complex subunit 7b

6

9

Small-scale

0.944

High

1115034

CUL4A
Cullin-4A

6

12

Small-scale

0.937

High

1112693

CUL1
Cullin-1

4

12

Small-scale

0.896

High

983955

RBX1
E3 ubiquitin-protein ligase RBX1

3

0

Small-scale

0.791

High

1112976

CUL2
Cullin-2

2

12

High-throughput

0.789

High

1371852

CUL5
Cullin-5

2

12

High-throughput

0.789

High

1363082

DDB2
DNA damage-binding protein 2

8

2

Small-scale

0.748

High

1154431

STK11
Serine/threonine-protein kinase STK11

4

1

High-throughput

0.694

High

1352266

DCA11
DDB1- and CUL4-associated factor 11

4

1

High-throughput

0.694

High

1388927

FBX17
F-box only protein 17

4

1

High-throughput

0.694

High

1157896

DDB1
DNA damage-binding protein 1

5

0

Small-scale

0.681

High

1098371

ERCC8
DNA excision repair protein ERCC-8

4

3

Small-scale

0.676

High

957497

UBC12
NEDD8-conjugating enzyme Ubc12

3

1

High-throughput

0.667

High

1413195

BTBD1
BTB/POZ domain-containing protein 1

3

5

High-throughput

0.667

High

1235386

KLH10
Kelch-like protein 10

3

3

High-throughput

0.662

High

1413188

CSN4
COP9 signalosome complex subunit 4

1

5

Small-scale

0.647

High

1413208

DTL
Denticleless protein homolog

3

3

Small-scale

0.640

High

1413221

DCAF1
DDB1- and CUL4-associated factor 1

3

1

Small-scale

0.640

High

1413219

FBX7
F-box only protein 7

3

0

High-throughput

0.634

High

1357543

DCAF4
DDB1- and CUL4-associated factor 4

2

1

High-throughput

0.628

High

1154919

NEDD8
Ubiquitin-like protein NEDD8

2

2

Small-scale

0.611

High

1413191

BTBD2
BTB/POZ domain-containing protein 2

2

6

High-throughput

0.611

High

220711

DENR
Density-regulated protein

2

0

High-throughput

0.602

High

342407

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

0

High-throughput

0.602

High

1272670

DET1
DET1 homolog

2

0

High-throughput

0.602

High

1413211

KLH13
Kelch-like protein 13

2

3

High-throughput

0.601

High

242758

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

1042917

ERCC6
DNA excision repair protein ERCC-6

2

1

Small-scale

0.584

High

1152034

PTN14
Tyrosine-protein phosphatase non-receptor type 14

2

4

Small-scale

0.584

High

278953

PEX14
Peroxisomal membrane protein PEX14

2

0

High-throughput

0.580

High

370769

FOS
Protein c-Fos

1

2

High-throughput

0.578

High

935069

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.575

High

160755

TOR1A
Torsin-1A

1

3

Small-scale

0.561

High

1147264

ELOB
Elongin-B

2

0

High-throughput

0.559

High

1403125

CRBN
Protein cereblon

2

0

Small-scale

0.559

High

167966

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.552

High

530305

TAU
Microtubule-associated protein tau

2

3

High-throughput

0.552

High

414522

P53
Cellular tumor antigen p53

2

0

Small-scale

0.547

High

1037814

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.536

High

1413218

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.536

High

1413206

KBTB4
Kelch repeat and BTB domain-containing protein 4

2

4

Small-scale

0.533

High

1413192

HEMGN
Hemogen

1

0

Small-scale

0.529

High

329166

RCBT2
RCC1 and BTB domain-containing protein 2

1

0

High-throughput

0.518

High

475677

K1C19
Keratin, type I cytoskeletal 19

1

0

High-throughput

0.518

High

943616

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

0

High-throughput

0.518

High

1154577

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1395282

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

1413204

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.518

High

1413212

WRP73
WD repeat-containing protein WRAP73

1

1

High-throughput

0.515

High

50929

SYCE3
Synaptonemal complex central element protein 3

1

0

High-throughput

0.513

High

484631

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1150472

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

0

High-throughput

0.513

High

1360281

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

1391950

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

1413205

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1413207

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.513

High

691381

1433T
14-3-3 protein theta

1

2

High-throughput

0.501

High

1200327

ANR39
Ankyrin repeat domain-containing protein 39

1

1

High-throughput

0.489

High

1413216

UBQL1
Ubiquilin-1

1

9

High-throughput

0.481

High

615233

IL1RA
Interleukin-1 receptor antagonist protein

1

0

Small-scale

0.480

High

1413201

RAB18
Ras-related protein Rab-18

1

0

Small-scale

0.480

High

1381270

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.479

High

218702

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

260384

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

315956

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

320839

KLH18
Kelch-like protein 18

1

3

High-throughput

0.479

High

333395

SNAPN
SNARE-associated protein Snapin

1

1

Small-scale

0.479

High

347903

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

508535

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

589556

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

607057

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

696362

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

762045

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

769034

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

945592

FBXW4
F-box/WD repeat-containing protein 4

1

2

Small-scale

0.479

High

990676

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

1067661

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1107154

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1110885

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.479

High

1229657

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1255303

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1258380

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1340799

COP1
E3 ubiquitin-protein ligase COP1

1

4

High-throughput

0.479

High

1347855

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

1359694

PHIP
PH-interacting protein

1

1

Small-scale

0.479

High

1360369

STON2
Stonin-2

1

1

Small-scale

0.479

High

1364563

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1380642

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1413194

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

1413199

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1413202

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

Small-scale

0.479

High

1413203

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

1413209

IBTK
Inhibitor of Bruton tyrosine kinase

1

2

Small-scale

0.479

High

1413210

KLH42
Kelch-like protein 42

1

4

High-throughput

0.479

High

1413214

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1413223

MAFB
Transcription factor MafB

1

3

High-throughput

0.479

High

1327164

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.470

High

342028

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

646927

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

975208

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

992318

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.458

High

997982

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.458

High

1034929

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

Small-scale

0.458

High

1139897

LRC14
Leucine-rich repeat-containing protein 14

1

0

High-throughput

0.458

High

1147117

ELOC
Elongin-C

1

0

High-throughput

0.458

High

1289588

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1289800

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1338341

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1368367

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1396699

LLR1
Leucine-rich repeat protein 1

1

0

High-throughput

0.458

High

1413190

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1413196

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1413215

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.458

High

1413220

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

430299

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

564305

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

1015726

RHOG
Rho-related GTP-binding protein RhoG

1

1

Small-scale

0.445

High

1136941

ABRX2
BRISC complex subunit Abraxas 2

1

1

Small-scale

0.445

High

1199027

KLH12
Kelch-like protein 12

1

3

High-throughput

0.445

High

1215358

DCAF8
DDB1- and CUL4-associated factor 8

1

3

High-throughput

0.445

High

1234931

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

1327588

WDTC1
WD and tetratricopeptide repeats protein 1

1

3

High-throughput

0.445

High

1395020

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

106573

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

318868

RHBT1
Rho-related BTB domain-containing protein 1

1

5

High-throughput

0.437

High

412527

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1332551

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

1

Small-scale

0.437

High

1413193

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

171564

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

404895

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1413197

FXL15
F-box/LRR-repeat protein 15

1

0

High-throughput

0.426

High

887182

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

1330069

USBP1
Harmonin-binding protein USHBP1

3

0

High-throughput

0.357

High

1413222

PCDBC
Protocadherin beta-12

2

0

High-throughput

0.316

High

1081595

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.304

High

1331847

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

1413189

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

1241943

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1359389

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.249

Low

1413198

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

947043

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

255191

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

922396

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.232

Low

1253204

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1271400

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.232

Low

1397968

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025