HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20724660
Identification Methods	enzymatic study
Interaction Type	ubiquitination reaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 145
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		607023 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (7-144): 6.23e-58: 178: 21.58
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (2-143): 6.26e-57: 178: 23.08
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (7-144): 2.17e-57: 177: 20.86
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (2-143): 7.87e-57: 177: 23.08
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (1-143): 2.16e-56: 176: 22.92
+	Hs
		607055 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (10-144): 1.59e-58: 180: 23.53
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (7-144): 6.43e-55: 171: 19.42
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (9-144): 3.56e-57: 176: 21.90
+	Sc
		410211 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (7-145): 2.77e-56: 175: 20.00
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		782203 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (1-143): 2.16e-56: 176: 22.92
+	Sp
		251976 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC1_SCHPO (11-130): 2.26e-13: 66.1: 28.10
+	Hs
		930429 SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01