HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2J2 (Q8N2K1)
Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)
Gene: UBE2J2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	27425610, 36563856
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 259
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (1-157): 8.61e-62: 194: 25.47
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (1-157): 3.56e-61: 193: 25.47
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (1-157): 7.51e-61: 192: 24.85
+	Hs
		607193 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2J1_HUMAN (7-152): 5.57e-56: 183: 39.46
+	Hs
		607023 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (10-157): 3.88e-56: 178: 26.32
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (11-127): 2.6e-16: 75.5: 34.71
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (12-156): 1.36e-64: 199: 24.16
+	Sp
		193850 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC6_SCHPO (8-169): 1.69e-55: 179: 52.76
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (12-156): 5.48e-63: 196: 23.49
+	Sc
		608684 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC6_YEAST (8-254): 3.25e-58: 187: 41.04
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		782203 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (1-157): 7.51e-61: 192: 24.85
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (11-122): 6.77e-16: 74.3: 34.48
+	Sc
		410211 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (11-127): 3.06e-17: 78.6: 36.36