Protein: MED20
Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (hTRFP)

Gene: MED20
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q9H944

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006351 - DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414141

MED18
Mediator of RNA polymerase II transcription subunit 18

12

2

Small-scale

0.985

High

1241414

MED27
Mediator of RNA polymerase II transcription subunit 27

5

1

Small-scale

0.930

High

1436779

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

High-throughput

0.927

High

881608

CDK8
Cyclin-dependent kinase 8

11

3

Small-scale

0.758

High

1413630

MED10
Mediator of RNA polymerase II transcription subunit 10

9

1

Small-scale

0.755

High

1436782

MED29
Mediator of RNA polymerase II transcription subunit 29

8

1

Small-scale

0.754

High

1151295

MED1
Mediator of RNA polymerase II transcription subunit 1

7

2

Small-scale

0.748

High

1372196

MED12
Mediator of RNA polymerase II transcription subunit 12

7

1

High-throughput

0.748

High

1431397

MED28
Mediator of RNA polymerase II transcription subunit 28

7

1

Small-scale

0.747

High

1393380

MED30
Mediator of RNA polymerase II transcription subunit 30

6

2

Small-scale

0.737

High

1416402

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

666911

CCNC
Cyclin-C

6

1

High-throughput

0.729

High

49018

MED19
Mediator of RNA polymerase II transcription subunit 19

9

0

Small-scale

0.724

High

219518

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

1436778

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.718

High

1108400

MED21
Mediator of RNA polymerase II transcription subunit 21

6

0

High-throughput

0.706

High

1391337

MED8
Mediator of RNA polymerase II transcription subunit 8

4

2

High-throughput

0.702

High

1436780

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.701

High

239619

MED14
Mediator of RNA polymerase II transcription subunit 14

4

3

High-throughput

0.699

High

287819

MED6
Mediator of RNA polymerase II transcription subunit 6

4

2

High-throughput

0.699

High

1149712

MED22
Mediator of RNA polymerase II transcription subunit 22

4

1

High-throughput

0.699

High

1436783

MED11
Mediator of RNA polymerase II transcription subunit 11

4

1

High-throughput

0.699

High

1436793

MED16
Mediator of RNA polymerase II transcription subunit 16

4

1

High-throughput

0.699

High

1436791

MED23
Mediator of RNA polymerase II transcription subunit 23

3

1

High-throughput

0.678

High

1436795

MED31
Mediator of RNA polymerase II transcription subunit 31

3

1

High-throughput

0.675

High

282420

MED24
Mediator of RNA polymerase II transcription subunit 24

4

0

High-throughput

0.670

High

336030

MED26
Mediator of RNA polymerase II transcription subunit 26

4

0

High-throughput

0.670

High

1259070

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

2

High-throughput

0.667

High

1401568

MED15
Mediator of RNA polymerase II transcription subunit 15

3

1

High-throughput

0.667

High

1436787

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

High-throughput

0.662

High

396971

ESR1
Estrogen receptor

3

3

Small-scale

0.660

High

507375

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

1

High-throughput

0.628

High

667458

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

High-throughput

0.628

High

1295676

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

1

High-throughput

0.611

High

188717

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

681928

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

1367301

ESR2
Estrogen receptor beta

2

3

Small-scale

0.595

High

621750

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.586

High

675685

TYY1
Transcriptional repressor protein YY1

2

0

High-throughput

0.580

High

1055676

GABP1
GA-binding protein subunit beta-1

2

0

High-throughput

0.580

High

1231246

NB5R2
NADH-cytochrome b5 reductase 2

2

0

High-throughput

0.580

High

1292746

TRI69
E3 ubiquitin-protein ligase TRIM69

2

0

High-throughput

0.580

High

607112

CEBPB
CCAAT/enhancer-binding protein beta

1

3

Small-scale

0.561

High

260470

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

1436777

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

1

High-throughput

0.541

High

135350

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.536

High

647448

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.536

High

654680

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.536

High

766861

PHB1
Prohibitin 1

1

1

High-throughput

0.536

High

854933

RECQ1
ATP-dependent DNA helicase Q1

1

1

High-throughput

0.536

High

931601

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.536

High

931709

RD23B
UV excision repair protein RAD23 homolog B

1

2

High-throughput

0.536

High

1125231

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.536

High

1259283

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.536

High

1329113

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.536

High

1341026

THOC2
THO complex subunit 2

1

2

High-throughput

0.536

High

1406041

PHB2
Prohibitin-2

1

1

High-throughput

0.536

High

1411715

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.536

High

192857

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

276525

PDCD6
Programmed cell death protein 6

1

0

High-throughput

0.513

High

295540

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

High-throughput

0.513

High

390185

ALBU
Albumin

1

0

High-throughput

0.513

High

580417

ALDR
Aldo-keto reductase family 1 member B1

1

0

High-throughput

0.513

High

621970

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

625631

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

641025

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

665721

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.513

High

679261

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.513

High

712279

TKT
Transketolase

1

0

High-throughput

0.513

High

770429

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.513

High

840090

CASP3
Caspase-3

1

0

High-throughput

0.513

High

856927

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.513

High

936214

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.513

High

938625

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.513

High

940186

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.513

High

949209

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.513

High

962500

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

974201

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.513

High

988214

TRA2B
Transformer-2 protein homolog beta

1

0

High-throughput

0.513

High

1023620

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1066782

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1093316

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.513

High

1099257

SRSF5
Serine/arginine-rich splicing factor 5

1

0

High-throughput

0.513

High

1125776

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

1232048

SUMO4
Small ubiquitin-related modifier 4

1

0

High-throughput

0.513

High

1243776

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1280506

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.513

High

1384024

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.513

High

1409664

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

1436781

SLTM
SAFB-like transcription modulator

1

0

High-throughput

0.513

High

508647

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

1253873

SRCAP
Helicase SRCAP

1

0

High-throughput

0.493

High

612308

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.489

High

1015126

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.489

High

1366036

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

1

High-throughput

0.481

High

590494

GATA1
Erythroid transcription factor

1

0

Small-scale

0.479

High

283549

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

316321

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.479

High

326375

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.479

High

404430

GCR
Glucocorticoid receptor

1

3

Small-scale

0.479

High

520379

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

723094

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

787790

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

887232

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

887468

CEBPD
CCAAT/enhancer-binding protein delta

1

3

Small-scale

0.479

High

1153915

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1154008

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

1193628

Q49AR9
ANKS1A protein

1

1

High-throughput

0.470

High

1234663

Q6IPE9
non-specific serine/threonine protein kinase

1

1

High-throughput

0.470

High

143263

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.458

High

401499

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

605274

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

0

Small-scale

0.458

High

860954

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.458

High

912128

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

912235

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.458

High

920282

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

923540

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

959058

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

976152

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

983707

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1026544

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1089019

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1118780

KLF5
Krueppel-like factor 5

1

0

Small-scale

0.458

High

1146830

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1212035

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1217615

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1257821

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1258314

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

1313052

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1380170

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1407417

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1436786

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

95758

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1195698

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

1

High-throughput

0.437

High

1227480

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1401874

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

76438

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

839507

PI4KA
Phosphatidylinositol 4-kinase alpha

1

1

High-throughput

0.407

High

352640

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

1359130

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.316

High

1387695

ERP27
Endoplasmic reticulum resident protein 27

2

0

High-throughput

0.316

High

1436789

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

0

High-throughput

0.316

High

1064699

CLM6
CMRF35-like molecule 6

1

0

High-throughput

0.282

High

215451

TPD54
Tumor protein D54

1

0

High-throughput

0.279

Low

248418

GDF9
Growth/differentiation factor 9

1

0

High-throughput

0.279

Low

361551

CERU
Ceruloplasmin

1

0

High-throughput

0.279

Low

369920

CO3
Complement C3

1

0

High-throughput

0.279

Low

483645

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

784727

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

784806

VATE1
V-type proton ATPase subunit E 1

1

0

High-throughput

0.279

Low

828679

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.279

Low

861501

GNPI1
Glucosamine-6-phosphate deaminase 1

1

0

High-throughput

0.279

Low

895653

SERPH
Serpin H1

1

0

High-throughput

0.279

Low

956790

RAB10
Ras-related protein Rab-10

1

0

High-throughput

0.279

Low

986867

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

0

High-throughput

0.279

Low

1007852

GSTO1
Glutathione S-transferase omega-1

1

0

High-throughput

0.279

Low

1092647

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.279

Low

1117485

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

High-throughput

0.279

Low

1146639

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

High-throughput

0.279

Low

1162739

QPCT
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.279

Low

1272119

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1277789

MYH14
Myosin-14

1

0

High-throughput

0.279

Low

1307850

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.279

Low

1322312

SPART
Spartin

1

0

High-throughput

0.279

Low

1323619

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.279

Low

1359541

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1400112

CMA1A
Ciliary microtubule associated protein 1A

1

0

High-throughput

0.279

Low

1416062

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.279

Low

1420341

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.279

Low

1436785

GBG12

1

0

High-throughput

0.279

Low

1436788

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.279

Low

1436790

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

1436792

COR1C
Coronin-1C

1

0

High-throughput

0.279

Low

1436794

SGT1
Protein SGT1 homolog

1

0

High-throughput

0.279

Low

1436796

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.279

Low

1396680

MARK4
MAP/microtubule affinity-regulating kinase 4

1

0

High-throughput

0.251

Low

387562

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

1142398

PDIA6
Protein disulfide-isomerase A6

1

0

High-throughput

0.249

Low

1143979

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.249

Low

1232020

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1364463

WASF1
Actin-binding protein WASF1

1

0

High-throughput

0.249

Low

1436784

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.249

Low

506029

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

516954

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025