HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2Z (Q9H832)
Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)
Gene: UBE2Z

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	25768649, 27425610, 36758106
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process and 1 others more... GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 354
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (99-253): 1.41e-72: 223: 33.12
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (99-253): 3.54e-72: 222: 34.40
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (99-253): 2.91e-71: 220: 31.85
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (99-253): 7.74e-71: 219: 34.40
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (44-253): 2.74e-65: 207: 24.53
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (74-253): 5.35e-65: 206: 27.47
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (82-253): 6.89e-65: 205: 27.01
+	Hs
		607169 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2T_HUMAN (99-291): 1.1e-61: 197: 27.14
+	Hs
		607022 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2R1_HUMAN (96-283): 9.14e-57: 186: 26.36
+	Hs
		607042 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2N_HUMAN (103-226): 3.77e-18: 82: 36.29
+	Hs
		48134 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UBE2Z_HUMAN (1-354): 2.59e-111: 330: 100.00
+	Dm
		715098 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		UBE2N_DROME (97-255): 3.5e-62: 197: 30.44
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (99-252): 1.27e-69: 216: 35.26
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (99-253): 3.84e-68: 212: 31.85
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (99-253): 3.54e-72: 222: 34.40
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (99-253): 2.91e-71: 220: 31.85
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (99-253): 7.74e-71: 219: 34.40
+	Hs
		48135 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UBE2T_HUMAN (99-291): 1.1e-61: 197: 27.14
+	At
		955614 UBE11_ARATH (7-1058): 0: 1106: 43.35		UBC26_ARATH (128-230): 9.51e-19: 89.4: 46.30
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (103-245): 7.78e-19: 84: 34.48