Protein: FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase)

Gene: FKBP3
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q00688

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005528 - FK506 binding
GO:0005634 - nucleus
GO:0038023 - signaling receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410776

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

11

High-throughput

0.743

High

395922

ESR1
Estrogen receptor

2

13

High-throughput

0.737

High

1026907

SRPK1
SRSF protein kinase 1

1

6

High-throughput

0.710

High

213899

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

5

High-throughput

0.691

High

529640

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.628

High

861570

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

5

High-throughput

0.619

High

1026879

KPCZ
Protein kinase C zeta type

1

9

High-throughput

0.618

High

1026896

MYLK4
Myosin light chain kinase family member 4

1

11

High-throughput

0.618

High

400663

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.618

High

656096

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

11

High-throughput

0.618

High

839242

MTOR
Serine/threonine-protein kinase mTOR

1

8

Small-scale

0.618

High

897743

CDK9
Cyclin-dependent kinase 9

1

13

High-throughput

0.618

High

964222

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.618

High

986344

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.618

High

1026880

TRI26
Tripartite motif-containing protein 26

1

1

Small-scale

0.618

High

1026920

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.618

High

1026877

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.586

High

675462

TYY1
Transcriptional repressor protein YY1

1

4

Small-scale

0.561

High

345680

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

411748

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.553

High

1026893

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

1026911

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

10

High-throughput

0.553

High

1026921

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.553

High

1026909

BARD1
BRCA1-associated RING domain protein 1

1

12

High-throughput

0.552

High

648143

NDKB
Nucleoside diphosphate kinase B

1

4

High-throughput

0.536

High

354668

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.514

High

943915

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

10

High-throughput

0.514

High

1026890

HS904
Putative heat shock protein HSP 90-alpha A4

1

18

High-throughput

0.514

High

1026900

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1026914

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1026899

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

1026906

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

5

High-throughput

0.489

High

690476

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.489

High

1026916

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.489

High

316812

MTA2
Metastasis-associated protein MTA2

1

0

Small-scale

0.480

High

241416

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

259803

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

413635

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

536981

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

566634

PDIA4
Protein disulfide-isomerase A4

1

17

High-throughput

0.479

High

606636

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

697845

CALR
Calreticulin

1

4

High-throughput

0.479

High

717286

PEBP1
Phosphatidylethanolamine-binding protein 1

1

8

High-throughput

0.479

High

772145

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

791296

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

813453

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

3

High-throughput

0.479

High

830574

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

904606

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

927236

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

941136

IF6
Eukaryotic translation initiation factor 6

1

2

High-throughput

0.479

High

964854

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

982401

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

1015967

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.479

High

1026878

EWS
RNA-binding protein EWS

1

7

High-throughput

0.479

High

1026881

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1026883

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

1026884

NACA
Nascent polypeptide-associated complex subunit alpha

1

5

High-throughput

0.479

High

1026885

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

High-throughput

0.479

High

1026886

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1026894

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1026901

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

1026902

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

4

High-throughput

0.479

High

1026903

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.479

High

1026908

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.479

High

1026918

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1026922

RBM8A
RNA-binding protein 8A

1

2

High-throughput

0.479

High

1026919

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.464

High

352400

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

459544

PROF1
Profilin-1

1

0

High-throughput

0.458

High

601629

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

635791

PTMS
Parathymosin

1

0

High-throughput

0.458

High

643787

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

659446

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

1010285

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

1026882

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.458

High

1026897

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

955067

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.457

High

1026913

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

5

Small-scale

0.457

High

318728

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.437

High

353251

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

380004

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

418067

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

616169

PGAM1
Phosphoglycerate mutase 1

1

4

High-throughput

0.437

High

687660

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

6

High-throughput

0.437

High

712186

TKT
Transketolase

1

6

High-throughput

0.437

High

1026891

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

1026910

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1026915

ANLN
Anillin

1

1

High-throughput

0.437

High

1026917

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

1026889

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

886756

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

942556

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.407

High

1026904

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.407

High

1026898

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

1026923

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

447741

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.249

Low

571415

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

599579

STMN1
Stathmin

1

0

High-throughput

0.249

Low

715541

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

1026888

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1026892

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1026905

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.249

Low

1026912

GARE1
GRB2-associated and regulator of MAPK protein 1

1

0

High-throughput

0.249

Low

1026887

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1026895

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025