HitPredict - High confidence protein-protein interactions

Interactor 1: MYD88 (P22366)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Interactor 2: TLR4 (Q9QUK6)
Toll-like receptor 4 (CD antigen CD284)
Gene: TLR4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.759

Property	Details
Experiments	18772134, 19378012, 19898473, 17618294, 10952994, 12941697, 19265160, 18927610, 17446211, 19027002, 21846723, 21911421, 25808990, 29990310, 23023391
Identification Methods	affinity chromatography technology, protein complementation assay, anti tag coimmunoprecipitation, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0005102 - signaling receptor binding GO:0005886 - plasma membrane GO:0006909 - phagocytosis GO:0006954 - inflammatory response and 29 others more... GO:0007254 - JNK cascade GO:0009986 - cell surface GO:0010467 - gene expression GO:0010628 - positive regulation of gene expression GO:0014004 - microglia differentiation GO:0022008 - neurogenesis GO:0031663 - lipopolysaccharide-mediated signaling pathway GO:0032496 - response to lipopolysaccharide GO:0032680 - regulation of tumor necrosis factor production GO:0032722 - positive regulation of chemokine production GO:0032731 - positive regulation of interleukin-1 beta production GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0034142 - toll-like receptor 4 signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045471 - response to ethanol GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046330 - positive regulation of JNK cascade GO:0048661 - positive regulation of smooth muscle cell proliferation GO:0050671 - positive regulation of lymphocyte proliferation GO:0050727 - regulation of inflammatory response GO:0060907 - positive regulation of macrophage cytokine production GO:0071222 - cellular response to lipopolysaccharide GO:0071260 - cellular response to mechanical stimulus GO:0140052 - cellular response to oxidised low-density lipoprotein particle stimulus GO:1900017 - positive regulation of cytokine production involved in inflammatory response GO:1900227 - positive regulation of NLRP3 inflammasome complex assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	296
Mm

1	835

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024