HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~I-set, I-set~TSP_1, Ig_3~I-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 945
+	Hs
		508096 FGFR1_HUMAN (3-794): 0: 706: 54.76		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		1072543 EPHA7_HUMAN (4-781): 0: 584: 19.90		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		872674 EPHA4_HUMAN (4-776): 0: 582: 19.47		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		872459 EPHA5_HUMAN (4-771): 0: 580: 18.81		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		665628 EPHB2_HUMAN (4-779): 0: 557: 17.27		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		665499 EPHA8_HUMAN (4-763): 0: 549: 19.79		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		968321 ROR1_HUMAN (11-777): 2.13e-168: 512: 21.04		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		1081529 NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		385149 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		434237 RET_HUMAN (221-802): 2.33e-148: 465: 34.72		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		306900 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		UNC5C_HUMAN (32-944): 0: 864: 63.75
+	Hs
		608212 FGFR4_HUMAN (13-802): 0: 750: 100.00		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		384706 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63
+	Hs
		674404 UFO_HUMAN (5-793): 5.98e-159: 486: 22.59		ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63
+	Hs
		385273 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		PXDN_HUMAN (2-262): 8.33e-41: 165: 17.80
+	Hs
		434263 RET_HUMAN (221-802): 2.33e-148: 465: 34.72		LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78
+	Mm
		724165 RET_MOUSE (221-802): 1.64e-145: 458: 34.22		LRIG1_MOUSE (1-561): 1.23e-43: 174: 12.94
+	Mm
		530201 NTRK2_MOUSE (122-757): 5e-166: 503: 26.62		NCAM1_MOUSE (49-293): 9.57e-24: 110: 14.23
+	Mm
		546312 NTRK2_MOUSE (122-757): 5e-166: 503: 26.62		AGRB3_MOUSE (173-327): 5.87e-12: 72.2: 21.97
+	Rn
		530224 Q63237_RAT (4-407): 1.18e-134: 408: 47.33		NCAM1_RAT (49-293): 4.55e-25: 114: 14.23