HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 1292
+	Hs
		557606 FGFR4_HUMAN (13-802): 0: 750: 100.00		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		208993 FGFR4_HUMAN (13-802): 0: 750: 100.00		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Hs
		297957 FGFR3_HUMAN (5-799): 0: 712: 61.07		FCSD2_HUMAN (340-994): 3.64e-50: 192: 11.44
+	Hs
		537595 FGFR3_HUMAN (5-799): 0: 712: 61.07		NCF1_HUMAN (701-1015): 3.76e-50: 185: 17.18
+	Hs
		507832 FGFR1_HUMAN (3-794): 0: 706: 54.76		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Rn
		499160 FGFR1_RAT (3-794): 0: 698: 54.27		PLCG1_RAT (394-868): 7.61e-43: 173: 12.47
+	Hs
		208983 FGFR1_HUMAN (3-794): 0: 706: 54.76		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Hs
		607984 FGFR4_HUMAN (13-802): 0: 750: 100.00		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		608159 FGFR4_HUMAN (13-802): 0: 750: 100.00		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Hs
		608000 FGFR4_HUMAN (13-802): 0: 750: 100.00		SH319_HUMAN (793-851): 9.71e-11: 68.4: 37.29
+	Hs
		608026 FGFR4_HUMAN (13-802): 0: 750: 100.00		SH3R1_HUMAN (220-850): 8.23e-10: 65.6: 13.22
+	Hs
		601605 FGFR2_HUMAN (4-797): 0: 737: 56.44		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Hs
		508022 FGFR1_HUMAN (3-794): 0: 706: 54.76		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		508233 FGFR1_HUMAN (3-794): 0: 706: 54.76		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Hs
		508045 FGFR1_HUMAN (3-794): 0: 706: 54.76		SH319_HUMAN (793-851): 9.71e-11: 68.4: 37.29
+	Hs
		557643 EPHA5_HUMAN (4-771): 0: 580: 18.81		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		557644 EPHB1_HUMAN (4-778): 0: 575: 17.73		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		209018 EPHA4_HUMAN (4-776): 0: 582: 19.47		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Hs
		208996 EPHA2_HUMAN (4-789): 0: 573: 19.58		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Hs
		665608 EPHB2_HUMAN (4-779): 0: 557: 17.27		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91