HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: FSTL4 (Q6MZW2)
Follistatin-related protein 4 (Follistatin-like protein 4)
Gene: FSTL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ig_3~I-set, Ig_3~Ig_3
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 842
+	Hs
		609173 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGFR3_HUMAN (186-595): 9.95e-62: 225: 18.08
+	Hs
		601456 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGFR2_HUMAN (110-658): 1.21e-59: 219: 15.28
+	Hs
		507857 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGFR1_HUMAN (176-595): 1.27e-55: 208: 15.71
+	Hs
		609252 FGFR3_HUMAN (10-806): 0: 819: 100.00		PGBM_HUMAN (213-366): 1.35e-12: 74.3: 17.95
+	Hs
		609225 EPHA4_HUMAN (1-781): 0: 622: 20.78		FGFR3_HUMAN (186-595): 9.95e-62: 225: 18.08
+	Hs
		601484 EPHA4_HUMAN (1-781): 0: 622: 20.78		FGFR2_HUMAN (110-658): 1.21e-59: 219: 15.28
+	Hs
		507926 EPHA4_HUMAN (1-781): 0: 622: 20.78		FGFR1_HUMAN (176-595): 1.27e-55: 208: 15.71
+	Hs
		609184 EPHA2_HUMAN (1-788): 0: 595: 21.50		FGFR3_HUMAN (186-595): 9.95e-62: 225: 18.08
+	Hs
		601465 EPHA2_HUMAN (1-788): 0: 595: 21.50		FGFR2_HUMAN (110-658): 1.21e-59: 219: 15.28
+	Hs
		507871 EPHA2_HUMAN (1-788): 0: 595: 21.50		FGFR1_HUMAN (176-595): 1.27e-55: 208: 15.71
+	Hs
		530151 EPHA3_HUMAN (1-786): 0: 641: 20.68		NCAM1_HUMAN (240-482): 8.55e-23: 106: 20.00
+	Hs
		1031134 NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59		PTK7_HUMAN (137-602): 3.72e-33: 140: 14.64
+	Hs
		384360 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		L1CAM_HUMAN (4-761): 4.19e-38: 155: 10.81
+	Mm
		530201 NTRK2_MOUSE (158-756): 2.71e-161: 490: 25.19		NCAM1_MOUSE (240-497): 1.47e-23: 109: 19.40
+	Hs
		384774 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		PTK7_HUMAN (137-602): 3.72e-33: 140: 14.64
+	Rn
		530224 Q63237_RAT (7-413): 2.16e-139: 421: 52.98		NCAM1_RAT (242-728): 2.7e-33: 140: 16.48
+	Hs
		384188 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		NCAM1_HUMAN (240-482): 8.55e-23: 106: 20.00
+	Hs
		385273 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		PXDN_HUMAN (16-237): 2.04e-19: 96.3: 12.16
+	Hs
		385252 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		TITIN_HUMAN (24-193): 2.1e-09: 63.9: 5.14
+	Mm
		724165 RET_MOUSE (454-788): 2.15e-100: 337: 51.90		LRIG1_MOUSE (242-483): 1.7e-38: 157: 23.92