HitPredict

Interactor 1: RFX1 (P22670)
MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1)
Gene: RFX1

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	27173435, 16464847, 17630394
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 979 Hs			1 482
+	Hs
		817520 RFX3_HUMAN (248-977): 0: 626: 56.05		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		817532 RFX3_HUMAN (248-977): 0: 626: 56.05		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		817570 RFX5_HUMAN (343-514): 1.09e-24: 112: 20.81		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		203227 SYNJ1_HUMAN (4-400): 4.43e-13: 75.9: 12.85		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1038592 CBP_HUMAN (62-420): 1.89e-09: 64: 13.37		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1270347 CBP_HUMAN (62-420): 1.89e-09: 64: 13.37		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		177346 CBP_HUMAN (62-420): 1.89e-09: 64: 13.37		HDAC3_HUMAN (9-434): 0: 574: 57.94
+	Mm
		101450 F8VPR5_MOUSE (73-486): 2.51e-10: 67.1: 10.38		HDA10_MOUSE (11-393): 4.64e-139: 416: 22.81