HitPredict

Interactor 1: CCNO (P22674)
Cyclin-O
Gene: CCNO

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 350 Hs			1 346
+	Hs
		303829 CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		538471 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		538497 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00
+	Hs
		625350 CCNA1_HUMAN (73-345): 7.93e-97: 296: 25.36		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		538521 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	At
		1106926 CCB13_ARATH (7-345): 7.29e-103: 310: 24.48		CDKD2_ARATH (1-345): 4.32e-135: 389: 51.45
+	Hs
		303821 CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		303843 CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37		CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09
+	At
		621661 CCB12_ARATH (5-345): 3.06e-102: 310: 24.86		CDKA1_ARATH (9-298): 7.86e-134: 384: 43.54
+	At
		1106930 CCB13_ARATH (7-345): 7.29e-103: 310: 24.48		CDKD3_ARATH (1-342): 5.25e-132: 383: 51.75
+	Hs
		414711 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		538522 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09
+	Mm
		509465 CCNB1_MOUSE (2-346): 4.73e-100: 303: 21.56		CDK1_MOUSE (9-298): 3.17e-133: 383: 43.35
+	Xl
		526765 CCNB1_XENLA (12-346): 2.47e-98: 298: 22.16		CDK1A_XENLA (9-304): 1e-134: 387: 43.48
+	At
		1106906 CCB12_ARATH (5-345): 3.06e-102: 310: 24.86		CKB21_ARATH (9-302): 2.14e-129: 374: 38.49
+	At
		1106907 CCB12_ARATH (5-345): 3.06e-102: 310: 24.86		CKB22_ARATH (9-302): 1.18e-129: 374: 39.80
+	Hs
		414855 CCNA1_HUMAN (73-345): 7.93e-97: 296: 25.36		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	At
		1103350 CCB12_ARATH (5-345): 3.06e-102: 310: 24.86		CKB12_ARATH (9-298): 1.82e-128: 371: 41.10
+	At
		621660 CCA23_ARATH (20-345): 7.15e-97: 296: 21.28		CDKA1_ARATH (9-298): 7.86e-134: 384: 43.54
+	At
		1103349 CCA23_ARATH (20-345): 7.15e-97: 296: 21.28		CKB12_ARATH (9-298): 1.82e-128: 371: 41.10