HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.772

The method score is based on:

Property Details
Experiments 7544353, 9461587, 18374639, 11944898, 11418612, 8941725, 11030146, 8896416, 19861161, 16135792, 9259313, 9174058, 9988765, 16219545, 8612729, 16289966, 8621719, 11157475, 7642581, 10918571 and 32 others

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Identification Methods affinity chromatography technology, enzymatic study, pull down, two hybrid, far western blotting, experimental interaction detection, two hybrid array, tandem affinity purification, anti bait coimmunoprecipitation, validated two hybrid and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
GO:0036312 - phosphatidylinositol 3-kinase regulatory subunit binding
and 2 others

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Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 906
Hs

1 724
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Last updated: 15 Jul 2024