Protein: 5HT1E
5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E)

Gene: 5HT1E, HTR1E
Organism: Homo sapiens
Interactions: 144
UniProt ID: P28566

Gene Ontology (top 5):
GO:0001586 - Gi/o-coupled serotonin receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0004993 - G protein-coupled serotonin receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

443673

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

3

5

High-throughput

0.662

High

704040

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

High-throughput

0.546

High

704002

ACTB
Actin, cytoplasmic 1

1

7

High-throughput

0.536

High

536562

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

704015

ACTBL
Beta-actin-like protein 2

1

7

High-throughput

0.489

High

610238

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.470

High

704057

OPTN
Optineurin

1

1

High-throughput

0.470

High

48533

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

133729

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.445

High

164259

NRP1
Neuropilin-1

1

2

High-throughput

0.445

High

190589

MRP4
ATP-binding cassette sub-family C member 4

1

2

High-throughput

0.445

High

230759

EXTL3
Exostosin-like 3

1

2

High-throughput

0.445

High

251197

RNBP6
Ran-binding protein 6

1

6

High-throughput

0.445

High

255987

S19A2
Thiamine transporter 1

1

1

High-throughput

0.445

High

270623

ATP9A
Probable phospholipid-transporting ATPase IIA

1

1

High-throughput

0.445

High

320432

TM63A
Mechanosensitive cation channel TMEM63A

1

1

High-throughput

0.445

High

419963

B3A2
Anion exchange protein 2

1

1

High-throughput

0.445

High

603847

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.445

High

624602

SL9A1
Sodium/hydrogen exchanger 1

1

1

High-throughput

0.445

High

627266

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

9

High-throughput

0.445

High

637848

NF1
Neurofibromin

1

2

High-throughput

0.445

High

703992

CTR1
High affinity cationic amino acid transporter 1

1

3

High-throughput

0.445

High

703993

MRP1
Multidrug resistance-associated protein 1

1

2

High-throughput

0.445

High

703998

AGRE5
Adhesion G protein-coupled receptor E5

1

4

High-throughput

0.445

High

704000

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

High-throughput

0.445

High

704003

AT2C1
Calcium-transporting ATPase type 2C member 1

1

5

High-throughput

0.445

High

704006

S39A6
Zinc transporter ZIP6

1

8

High-throughput

0.445

High

704009

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.445

High

704010

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

1

High-throughput

0.445

High

704012

MSMO1
Methylsterol monooxygenase 1

1

2

High-throughput

0.445

High

704013

ANO6
Anoctamin-6

1

2

High-throughput

0.445

High

704017

AG10B
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

1

High-throughput

0.445

High

704019

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.445

High

704022

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

2

High-throughput

0.445

High

704033

LRP10
Low-density lipoprotein receptor-related protein 10

1

2

High-throughput

0.445

High

704037

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

5

High-throughput

0.445

High

704044

TM87A
Transmembrane protein 87A

1

2

High-throughput

0.445

High

704047

RAI3
Retinoic acid-induced protein 3

1

6

High-throughput

0.445

High

704048

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.445

High

704052

RAB2B
Ras-related protein Rab-2B

1

1

High-throughput

0.445

High

704069

FRMD8
FERM domain-containing protein 8

1

1

High-throughput

0.445

High

704072

YIPF3
Protein YIPF3

1

1

High-throughput

0.445

High

704077

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.445

High

704080

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.445

High

704083

SERC1
Serine incorporator 1

1

1

High-throughput

0.445

High

704092

LCAP
Leucyl-cystinyl aminopeptidase

1

3

High-throughput

0.445

High

704096

LRP12
Low-density lipoprotein receptor-related protein 12

1

3

High-throughput

0.445

High

704098

AGRG1
Adhesion G-protein coupled receptor G1

1

4

High-throughput

0.445

High

336261

BRI3
Membrane protein BRI3

1

0

High-throughput

0.426

High

397579

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.426

High

603749

ITA2
Integrin alpha-2

1

0

High-throughput

0.426

High

703995

HD
Huntingtin

1

0

High-throughput

0.426

High

704007

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

High-throughput

0.426

High

704020

WLS
Protein wntless homolog

1

0

High-throughput

0.426

High

704039

CDAN1
Codanin-1

1

0

High-throughput

0.426

High

704050

SPPL3
Signal peptide peptidase-like 3

1

0

High-throughput

0.426

High

704053

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.426

High

704054

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.426

High

704059

SPTCS
Spatacsin

1

0

High-throughput

0.426

High

704061

PANX1
Pannexin-1

1

0

High-throughput

0.426

High

704064

MGST2
Microsomal glutathione S-transferase 2

1

0

High-throughput

0.426

High

704089

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.426

High

173662

BTAF1
TATA-binding protein-associated factor 172

1

2

High-throughput

0.407

High

184967

SPTC2
Serine palmitoyltransferase 2

1

1

High-throughput

0.407

High

193681

TPSN
Tapasin

1

1

High-throughput

0.407

High

226406

SNG2
Synaptogyrin-2

1

2

High-throughput

0.407

High

317800

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.407

High

318118

IPO13
Importin-13

1

10

High-throughput

0.407

High

350528

CF047
Uncharacterized protein C6orf47

1

2

High-throughput

0.407

High

399661

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

High-throughput

0.407

High

536238

PPAL
Lysosomal acid phosphatase

1

2

High-throughput

0.407

High

693388

CERS1
Ceramide synthase 1

1

10

High-throughput

0.407

High

704001

CLCN7
H(+)/Cl(-) exchange transporter 7

1

1

High-throughput

0.407

High

704004

KDSR
3-ketodihydrosphingosine reductase

1

5

High-throughput

0.407

High

704005

ATM
Serine-protein kinase ATM

1

9

High-throughput

0.407

High

704011

TRAM2
Translocating chain-associated membrane protein 2

1

10

High-throughput

0.407

High

704014

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

2

High-throughput

0.407

High

704018

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.407

High

704023

ZFY26
Zinc finger FYVE domain-containing protein 26

1

2

High-throughput

0.407

High

704024

RINT1
RAD50-interacting protein 1

1

2

High-throughput

0.407

High

704025

BRAT1
Integrator complex assembly factor BRAT1

1

1

High-throughput

0.407

High

704027

THADA
tRNA

1

1

High-throughput

0.407

High

704028

CERS6
Ceramide synthase 6

1

10

High-throughput

0.407

High

704029

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

1

High-throughput

0.407

High

704030

DYM
Dymeclin

1

2

High-throughput

0.407

High

704031

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

1

High-throughput

0.407

High

704032

SETX
Probable helicase senataxin

1

1

High-throughput

0.407

High

704041

INT1
Integrator complex subunit 1

1

1

High-throughput

0.407

High

704042

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

1

High-throughput

0.407

High

704043

CERS5
Ceramide synthase 5

1

10

High-throughput

0.407

High

704045

RETR2
Reticulophagy regulator 2

1

3

High-throughput

0.407

High

704046

ZNT7
Zinc transporter 7

1

2

High-throughput

0.407

High

704049

GOGA5
Golgin subfamily A member 5

1

3

High-throughput

0.407

High

704055

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.407

High

704060

MIA2
Melanoma inhibitory activity protein 2

1

2

High-throughput

0.407

High

704063

CLCC1
Chloride channel CLIC-like protein 1

1

1

High-throughput

0.407

High

704065

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.407

High

704067

PTSS2
Phosphatidylserine synthase 2

1

3

High-throughput

0.407

High

704071

XPO4
Exportin-4

1

4

High-throughput

0.407

High

704074

F234A
Protein FAM234A

1

1

High-throughput

0.407

High

704076

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.407

High

704082

EPG5
Ectopic P granules protein 5 homolog

1

1

High-throughput

0.407

High

704084

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

1

High-throughput

0.407

High

704085

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.407

High

704086

T161A
Transmembrane protein 161A

1

1

High-throughput

0.407

High

704087

STX18
Syntaxin-18

1

1

High-throughput

0.407

High

704088

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.407

High

704090

IPO11
Importin-11

1

9

High-throughput

0.407

High

704091

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.407

High

704094

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

1

High-throughput

0.407

High

704095

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.407

High

704097

TNPO3
Transportin-3

1

12

High-throughput

0.407

High

704099

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.407

High

704070

CFA74
Cilia- and flagella-associated protein 74

2

0

High-throughput

0.318

High

703999

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.299

High

703996

PRS6B
26S proteasome regulatory subunit 6B

1

0

High-throughput

0.269

Low

64754

RIMC1
RAB7A-interacting MON1-CCZ1 complex subunit 1

1

0

High-throughput

0.232

Low

219276

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.232

Low

220475

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

High-throughput

0.232

Low

244323

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.232

Low

316482

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.232

Low

576090

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.232

Low

703994

CUX1
Homeobox protein cut-like 1

1

0

High-throughput

0.232

Low

703997

AT5G3
ATP synthase F(0) complex subunit C3, mitochondrial

1

0

High-throughput

0.232

Low

704008

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

0

High-throughput

0.232

Low

704016

YIF1B
Protein YIF1B

1

0

High-throughput

0.232

Low

704021

FOCAD
Focadhesin

1

0

High-throughput

0.232

Low

704026

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.232

Low

704034

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.232

Low

704035

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

1

0

High-throughput

0.232

Low

704036

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.232

Low

704038

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.232

Low

704051

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.232

Low

704056

INT12
Integrator complex subunit 12

1

0

High-throughput

0.232

Low

704058

INT4
Integrator complex subunit 4

1

0

High-throughput

0.232

Low

704062

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.232

Low

704066

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.232

Low

704068

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.232

Low

704073

INT2
Integrator complex subunit 2

1

0

High-throughput

0.232

Low

704075

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.232

Low

704078

TM245
Transmembrane protein 245

1

0

High-throughput

0.232

Low

704079

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.232

Low

704081

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.232

Low

704093

DOLK
Dolichol kinase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025