HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UBS3A (P57075)
Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
Gene: UBASH3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	31659016, 17709377, 15159412, 15107835, 16429130
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 661
+	Mm
		610596 CBL_MOUSE (1-906): 0: 888: 91.59		UBS3A_MOUSE (1-661): 0: 984: 78.40
+	Hs
		883333 CBLB_HUMAN (23-901): 0: 793: 46.65		UBS3A_HUMAN (1-661): 0: 1048: 100.00
+	Hs
		610459 CBL_HUMAN (1-906): 0: 917: 100.00		UBS3B_HUMAN (1-655): 0: 904: 43.07
+	Mm
		610620 CBL_MOUSE (1-906): 0: 888: 91.59		UBS3B_MOUSE (1-655): 0: 897: 42.77
+	Hs
		235473 CBL_HUMAN (1-906): 0: 917: 100.00		VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86
+	Hs
		298949 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37
+	Hs
		610501 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS1_HUMAN (145-339): 1.51e-20: 99.1: 21.46
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		610437 CBL_HUMAN (1-906): 0: 917: 100.00		Q6ICN0_HUMAN (245-341): 1.07e-21: 95.7: 25.25
+	Mm
		610595 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS2_MOUSE (200-339): 3.02e-23: 107: 21.05
+	Mm
		610608 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS1_MOUSE (234-339): 4.67e-22: 103: 24.53
+	Hs
		610540 CBL_HUMAN (1-906): 0: 917: 100.00		CD2AP_HUMAN (155-343): 1.01e-12: 73.3: 18.75
+	Mm
		610598 CBL_MOUSE (1-906): 0: 888: 91.59		GRB2_MOUSE (245-341): 1.89e-22: 98: 24.24
+	Mm
		610651 CBL_MOUSE (1-906): 0: 888: 91.59		CD2AP_MOUSE (155-343): 1.97e-13: 75.6: 19.39
+	Rn
		88774 D3ZV15_RAT (1-883): 0: 833: 89.00		GRB2_RAT (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		235501 CBLB_HUMAN (23-901): 0: 793: 46.65		VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86
+	Hs
		298976 CBLB_HUMAN (23-901): 0: 793: 46.65		SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37
+	Mm
		82735 B9EKI5_MOUSE (23-901): 0: 799: 47.22		GRB2_MOUSE (245-341): 1.89e-22: 98: 24.24
+	Hs
		924539 CBLB_HUMAN (23-901): 0: 793: 46.65		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		1027613 CBLB_HUMAN (23-901): 0: 793: 46.65		SH3R1_HUMAN (194-337): 1.29e-18: 92.6: 18.42