HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	35271311, 36931259, 11697890, 36470425, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0045296 - cadherin binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 255
+	Mm
		610571 CBL_MOUSE (1-906): 0: 888: 91.59		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		297821 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909712 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909755 PHLB1_HUMAN (503-868): 1.01e-10: 68: 9.74		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		257595 ANR17_HUMAN (410-903): 9.9e-09: 61.5: 11.51		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00