HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	7629518, 10826882, 9408950, 10427990
Identification Methods	pull down, x-ray crystallography, unspecified method, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 659
+	Hs
		610373 CBL_HUMAN (1-906): 0: 917: 100.00		ITK_HUMAN (4-657): 0: 688: 49.09
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (155-653): 0: 529: 34.35
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (164-653): 1.04e-178: 520: 35.14
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (34-659): 6.29e-165: 518: 32.72
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (148-653): 6.89e-174: 507: 34.93
+	Hs
		454799 CBL_HUMAN (1-906): 0: 917: 100.00		FGR_HUMAN (152-653): 2.33e-173: 506: 32.56
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (181-659): 2.77e-165: 505: 38.76
+	Mm
		610554 CBL_MOUSE (1-906): 0: 888: 91.59		FYN_MOUSE (155-653): 0: 530: 34.16
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (207-653): 1.53e-171: 500: 38.14
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (169-659): 5.79e-163: 500: 37.70
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (207-658): 2.35e-170: 495: 36.01
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (154-653): 1.58e-168: 493: 34.92
+	Mm
		403415 CBL_MOUSE (1-906): 0: 888: 91.59		SRC_MOUSE (164-653): 9.58e-178: 517: 35.14
+	Mm
		536206 CBL_MOUSE (1-906): 0: 888: 91.59		FGR_MOUSE (155-653): 1.7e-176: 514: 32.94
+	Hs
		610303 CBL_HUMAN (1-906): 0: 917: 100.00		BLK_HUMAN (156-653): 1.82e-164: 482: 35.98
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (181-659): 1.81e-165: 505: 38.76
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (148-653): 7.48e-173: 504: 34.10
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (207-653): 2.88e-171: 500: 37.69
+	Mm
		610545 CBL_MOUSE (1-906): 0: 888: 91.59		LYN_MOUSE (154-653): 7.83e-170: 496: 35.12