HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SLAP1 (Q13239)
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
Gene: SLA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	18193084, 10449770, 16327786, 17237826
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 276
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (24-275): 3.54e-89: 276: 28.52
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (3-275): 2.2e-87: 271: 27.02
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		454799 CBL_HUMAN (1-906): 0: 917: 100.00		FGR_HUMAN (13-275): 3.36e-87: 270: 26.64
+	Hs
		610303 CBL_HUMAN (1-906): 0: 917: 100.00		BLK_HUMAN (4-275): 9.14e-85: 263: 30.14
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (2-275): 9.81e-78: 258: 23.40
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (2-276): 2.45e-91: 281: 30.53
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		610373 CBL_HUMAN (1-906): 0: 917: 100.00		ITK_HUMAN (5-275): 1.59e-76: 245: 21.53
+	Hs
		610368 CBL_HUMAN (1-906): 0: 917: 100.00		BTK_HUMAN (22-276): 1.07e-75: 244: 17.91
+	Mm
		403415 CBL_MOUSE (1-906): 0: 888: 91.59		SRC_MOUSE (2-274): 3.56e-87: 271: 27.47
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (2-275): 2.88e-84: 263: 28.17
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (15-275): 1.13e-73: 233: 20.44
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (2-275): 3.95e-79: 260: 23.40
+	Hs
		610509 CBL_HUMAN (1-906): 0: 917: 100.00		SLAP2_HUMAN (12-248): 1.98e-74: 229: 40.74
+	Mm
		292681 CBL_MOUSE (1-906): 0: 888: 91.59		GRAP2_MOUSE (43-160): 1.24e-11: 65.9: 35.29