Protein: PSB5
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)

Gene: PSB5, PSMB5
Organism: Homo sapiens
Interactions: 198
UniProt ID: P28074

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

594458

PSB1
Proteasome subunit beta type-1

7

20

Small-scale

0.968

High

637634

PSA2
Proteasome subunit alpha type-2

8

19

Small-scale

0.966

High

656796

POMP
Proteasome maturation protein

6

14

Small-scale

0.949

High

656680

PSB3
Proteasome subunit beta type-3

6

19

Small-scale

0.949

High

656759

PSB7
Proteasome subunit beta type-7

6

18

Small-scale

0.948

High

656093

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.927

High

656681

PSB2
Proteasome subunit beta type-2

5

19

Small-scale

0.919

High

656417

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.902

High

637328

PSA1
Proteasome subunit alpha type-1

4

20

Small-scale

0.897

High

656152

PSA5
Proteasome subunit alpha type-5

2

20

High-throughput

0.811

High

656716

PSME4
Proteasome activator complex subunit 4

2

11

High-throughput

0.811

High

656677

PRS6B
26S proteasome regulatory subunit 6B

2

20

Small-scale

0.789

High

656694

PRS4
26S proteasome regulatory subunit 4

2

20

Small-scale

0.789

High

656695

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.789

High

637777

PSA3
Proteasome subunit alpha type-3

2

20

Small-scale

0.768

High

656559

PSB6
Proteasome subunit beta type-6

2

16

Small-scale

0.757

High

572866

PRS6A
26S proteasome regulatory subunit 6A

2

20

Small-scale

0.754

High

638070

PSA4
Proteasome subunit alpha type-4

2

20

Small-scale

0.754

High

656672

PRS7
26S proteasome regulatory subunit 7

2

20

Small-scale

0.737

High

656802

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

5

17

Small-scale

0.716

High

130757

PSDE
26S proteasome non-ATPase regulatory subunit 14

5

20

Small-scale

0.702

High

656692

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.699

High

121692

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

20

High-throughput

0.691

High

156233

PSA7
Proteasome subunit alpha type-7

1

20

High-throughput

0.691

High

656038

PSB8
Proteasome subunit beta type-8

1

19

High-throughput

0.691

High

656704

PSME1
Proteasome activator complex subunit 1

1

20

High-throughput

0.691

High

656688

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

4

10

Small-scale

0.683

High

167670

LSM1
U6 snRNA-associated Sm-like protein LSm1

3

2

High-throughput

0.661

High

656691

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

13

Small-scale

0.656

High

656703

UBE3A
Ubiquitin-protein ligase E3A

3

17

Small-scale

0.640

High

656717

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

20

High-throughput

0.621

High

656801

TRAF6
TNF receptor-associated factor 6

2

4

High-throughput

0.612

High

345996

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.611

High

656707

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

20

Small-scale

0.611

High

314007

BAG4
BAG family molecular chaperone regulator 4

2

3

High-throughput

0.606

High

656732

DUS29
Dual specificity phosphatase 29

2

2

High-throughput

0.606

High

656767

TCHP
Trichoplein keratin filament-binding protein

2

2

High-throughput

0.606

High

656804

NEMO
NF-kappa-B essential modulator

2

2

High-throughput

0.606

High

496369

TAU
Microtubule-associated protein tau

2

6

High-throughput

0.601

High

226593

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.584

High

656675

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

656720

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

9

Small-scale

0.584

High

656730

DDI2
Protein DDI1 homolog 2

2

20

Small-scale

0.584

High

656769

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

2

Small-scale

0.584

High

656753

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

2

0

High-throughput

0.580

High

656757

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

92607

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.575

High

108929

H0YKT8
Proteasome subunit beta

1

19

High-throughput

0.575

High

200768

ARHG9
Rho guanine nucleotide exchange factor 9

2

2

High-throughput

0.571

High

656728

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

656747

CC150
Coiled-coil domain-containing protein 150

2

2

High-throughput

0.553

High

121945

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

20

High-throughput

0.536

High

198553

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

10

High-throughput

0.536

High

236884

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

8

High-throughput

0.536

High

362850

FINC
Fibronectin

1

2

High-throughput

0.536

High

437915

HS90B
Heat shock protein HSP 90-beta

1

5

Small-scale

0.536

High

528601

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

656683

PSN1
Presenilin-1

1

3

High-throughput

0.536

High

656697

SKP1
S-phase kinase-associated protein 1

1

7

High-throughput

0.536

High

656698

CDKL1
Cyclin-dependent kinase-like 1

1

6

High-throughput

0.536

High

656711

CUL1
Cullin-1

1

6

High-throughput

0.536

High

656719

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

12

High-throughput

0.536

High

656731

ECM29
Proteasome adapter and scaffold protein ECM29

1

11

High-throughput

0.536

High

656743

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

6

High-throughput

0.536

High

656746

ARRD4
Arrestin domain-containing protein 4

1

7

High-throughput

0.536

High

656748

ARRD2
Arrestin domain-containing protein 2

1

7

High-throughput

0.536

High

656755

PSMG2
Proteasome assembly chaperone 2

1

11

High-throughput

0.536

High

656765

SLX1
Structure-specific endonuclease subunit SLX1

1

3

High-throughput

0.536

High

656776

TXNIP
Thioredoxin-interacting protein

1

7

High-throughput

0.536

High

656791

AMFR
E3 ubiquitin-protein ligase AMFR

1

12

High-throughput

0.536

High

656794

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

14

High-throughput

0.536

High

656799

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

6

High-throughput

0.536

High

656773

ADT4
ADP/ATP translocase 4

1

2

High-throughput

0.515

High

656803

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

135925

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

5

Small-scale

0.501

High

171482

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

316801

KLF8
Krueppel-like factor 8

1

17

High-throughput

0.500

High

507375

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.500

High

656761

FEV
Protein FEV

1

2

High-throughput

0.500

High

656763

ELF4
ETS-related transcription factor Elf-4

1

2

High-throughput

0.500

High

656768

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.500

High

305731

ELP1
Elongator complex protein 1

1

0

Small-scale

0.493

High

135380

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

6

High-throughput

0.479

High

160395

AURKA
Aurora kinase A

1

6

High-throughput

0.479

High

175645

TRI18
E3 ubiquitin-protein ligase Midline-1

1

16

Small-scale

0.479

High

201758

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

243977

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

255531

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

294406

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

302940

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

304792

MFN2
Mitofusin-2

1

4

High-throughput

0.479

High

324243

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.479

High

393053

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

397800

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

431559

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.479

High

455117

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

475371

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.479

High

487155

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

503493

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

505559

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

508833

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.479

High

552006

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

570483

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

5

High-throughput

0.479

High

596192

NEBU
Nebulin

1

1

High-throughput

0.479

High

650432

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

656670

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

656671

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

656673

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

656674

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

656678

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.479

High

656679

YAP1
Transcriptional coactivator YAP1

1

9

Small-scale

0.479

High

656682

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

656685

PLK1
Serine/threonine-protein kinase PLK1

1

14

Small-scale

0.479

High

656686

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

656687

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

656689

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

656690

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

656693

UBC12
NEDD8-conjugating enzyme Ubc12

1

10

High-throughput

0.479

High

656696

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

656699

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

10

High-throughput

0.479

High

656700

TOP2B
DNA topoisomerase 2-beta

1

2

Small-scale

0.479

High

656705

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

656706

DUS4
Dual specificity protein phosphatase 4

1

1

High-throughput

0.479

High

656708

ERCC8
DNA excision repair protein ERCC-8

1

6

Small-scale

0.479

High

656709

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

656710

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

656713

TRI14
Tripartite motif-containing protein 14

1

7

High-throughput

0.479

High

656714

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

4

Small-scale

0.479

High

656718

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

656721

TBR1
T-box brain protein 1

1

2

High-throughput

0.479

High

656724

LARP7
La-related protein 7

1

4

High-throughput

0.479

High

656726

MIDN
Midnolin

1

5

High-throughput

0.479

High

656727

AKIR2
Akirin-2

1

10

Small-scale

0.479

High

656733

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

656734

DESI1
Desumoylating isopeptidase 1

1

4

Small-scale

0.479

High

656735

CEP85
Centrosomal protein of 85 kDa

1

4

High-throughput

0.479

High

656736

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

656737

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

656738

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.479

High

656740

GOLI
E3 ubiquitin-protein ligase RNF130

1

16

High-throughput

0.479

High

656742

CDK20
Cyclin-dependent kinase 20

1

5

High-throughput

0.479

High

656744

RN149
E3 ubiquitin-protein ligase RNF149

1

16

High-throughput

0.479

High

656749

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

1

High-throughput

0.479

High

656752

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.479

High

656754

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

656758

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

6

Small-scale

0.479

High

656760

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

656762

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

656764

BAG1
BAG family molecular chaperone regulator 1

1

2

High-throughput

0.479

High

656770

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

7

Small-scale

0.479

High

656771

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

9

High-throughput

0.479

High

656775

ATG5
Autophagy protein 5

1

3

Small-scale

0.479

High

656778

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

656779

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

3

High-throughput

0.479

High

656781

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

656782

ANLN
Anillin

1

1

High-throughput

0.479

High

656783

UBQL4
Ubiquilin-4

1

20

Small-scale

0.479

High

656784

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

656786

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

656788

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

656789

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

656790

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

16

Small-scale

0.479

High

656792

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

656793

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

656795

HDAC5
Histone deacetylase 5

1

3

High-throughput

0.479

High

656797

NINL
Ninein-like protein

1

4

High-throughput

0.479

High

656798

FBX7
F-box only protein 7

1

6

High-throughput

0.479

High

656800

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

656741

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

214103

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

508350

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

656676

MAGA3
Melanoma-associated antigen 3

1

0

Small-scale

0.458

High

656684

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

656701

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.458

High

656702

ERCC6
DNA excision repair protein ERCC-6

1

0

Small-scale

0.458

High

656712

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

656722

FSCN1
Fascin

1

0

High-throughput

0.458

High

656751

RND1
Rho-related GTP-binding protein Rho6

1

0

Small-scale

0.458

High

656756

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

656787

TRM7
tRNA

1

0

High-throughput

0.458

High

656766

PSMG3
Proteasome assembly chaperone 3

1

5

Small-scale

0.457

High

691

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.445

High

401469

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

656739

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

18

High-throughput

0.445

High

656774

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

656777

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.445

High

100510

APRIO
Alternative prion protein

1

1

Small-scale

0.439

High

477811

GG12I
G antigen 12I

1

1

High-throughput

0.439

High

656725

GAG2E
G antigen 2E

1

1

High-throughput

0.439

High

329395

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

656715

GRM2
Metabotropic glutamate receptor 2

1

5

High-throughput

0.437

High

656723

PKHN1
Pleckstrin homology domain-containing family N member 1

1

1

Small-scale

0.437

High

656750

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

656772

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

656785

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

656729

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

Small-scale

0.426

High

656745

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

656780

LFG4
Protein lifeguard 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024