HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.759

The method score is based on:

Property Details
Experiments 8947469, 9174058, 9013636, 10940298, 10391678, 20133944, 11406619, 15581361, 16798838, 10799548, 9890970, 9115297, 15581362, 17420256, 10633073, 27474268
Identification Methods affinity chromatography technology
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0019901 - protein kinase binding
GO:0030971 - receptor tyrosine kinase binding
GO:0036312 - phosphatidylinositol 3-kinase regulatory subunit binding
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 913
Mm

1 724
+ Hs
+ Rn
+ Mm
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+ Mm
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+ Rn
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+ Hs

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Last updated: 15 Jul 2024