HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: CSK (P41241)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK)
Gene: CSK

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation GO:1990782 - protein tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 450
+	Hs
		610276 CBL_HUMAN (1-913): 0: 894: 91.05		CSK_HUMAN (1-450): 0: 548: 99.11
+	Mm
		337618 CBL_MOUSE (1-913): 0: 923: 100.00		ABL1_MOUSE (5-446): 4.66e-165: 495: 38.14
+	Mm
		610554 CBL_MOUSE (1-913): 0: 923: 100.00		FYN_MOUSE (12-442): 3.41e-171: 493: 37.22
+	Mm
		403415 CBL_MOUSE (1-913): 0: 923: 100.00		SRC_MOUSE (12-442): 1.78e-169: 488: 40.00
+	Mm
		411917 CBL_MOUSE (1-913): 0: 923: 100.00		LCK_MOUSE (6-443): 8.43e-169: 485: 38.41
+	Mm
		536206 CBL_MOUSE (1-913): 0: 923: 100.00		FGR_MOUSE (12-442): 1.12e-165: 478: 37.75
+	Mm
		435877 CBL_MOUSE (1-913): 0: 923: 100.00		HCK_MOUSE (7-445): 4.83e-163: 471: 36.56
+	Mm
		610545 CBL_MOUSE (1-913): 0: 923: 100.00		LYN_MOUSE (4-445): 1.24e-161: 467: 37.69
+	Hs
		337348 CBL_HUMAN (1-913): 0: 894: 91.05		ABL1_HUMAN (5-446): 1.08e-164: 495: 38.14
+	Hs
		69201 CBL_HUMAN (1-913): 0: 894: 91.05		A9UF07_HUMAN (5-446): 1.39e-159: 495: 38.14
+	Hs
		412013 CBL_HUMAN (1-913): 0: 894: 91.05		FYN_HUMAN (12-442): 2.68e-171: 493: 37.22
+	Hs
		433254 CBL_HUMAN (1-913): 0: 894: 91.05		YES_HUMAN (12-442): 1.06e-170: 491: 37.75
+	Hs
		522778 CBL_HUMAN (1-913): 0: 894: 91.05		SRC_HUMAN (12-442): 8.06e-171: 491: 39.78
+	Hs
		610281 CBL_HUMAN (1-913): 0: 894: 91.05		ABL2_HUMAN (4-445): 2.16e-161: 488: 39.38
+	Hs
		411595 CBL_HUMAN (1-913): 0: 894: 91.05		LCK_HUMAN (6-443): 1.62e-168: 485: 38.85
+	Hs
		442780 CBL_HUMAN (1-913): 0: 894: 91.05		HCK_HUMAN (3-445): 2.83e-167: 482: 36.90
+	Hs
		454799 CBL_HUMAN (1-913): 0: 894: 91.05		FGR_HUMAN (12-442): 2.64e-166: 480: 38.88
+	Hs
		433577 CBL_HUMAN (1-913): 0: 894: 91.05		LYN_HUMAN (4-445): 1.69e-161: 467: 37.91
+	Hs
		610303 CBL_HUMAN (1-913): 0: 894: 91.05		BLK_HUMAN (8-445): 3.15e-158: 458: 37.03
+	Rn
		88775 D3ZV15_RAT (1-877): 0: 852: 96.24		LYN_RAT (4-445): 7.88e-162: 468: 37.69