HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PK3CG (Q9JHG7)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: Pik3cg

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	9115297
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0046875 - ephrin receptor binding GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 913 Mm			1 1102
+	Mm
		193567 CBL_MOUSE (1-913): 0: 923: 100.00		PK3CD_MOUSE (23-1091): 0: 1045: 30.24
+	Mm
		610624 CBL_MOUSE (1-913): 0: 923: 100.00		PK3CB_MOUSE (38-1091): 0: 1010: 32.01
+	Mm
		610557 CBL_MOUSE (1-913): 0: 923: 100.00		PK3CA_MOUSE (23-1093): 0: 979: 32.32
+	Hs
		610280 CBL_HUMAN (1-913): 0: 894: 91.05		PK3CB_HUMAN (38-1091): 0: 989: 31.82
+	Hs
		610279 CBL_HUMAN (1-913): 0: 894: 91.05		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Hs
		128867 SNPC4_HUMAN (503-874): 7.25e-09: 61.9: 13.04		P3C2A_HUMAN (317-1095): 0: 741: 31.65