Protein: MIB2
E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)

Gene: MIB2
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q96AX9

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003779 - actin binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1383740

PD1L1
Programmed cell death 1 ligand 1

1

8

Small-scale

0.747

High

1383741

TBK1
Serine/threonine-protein kinase TBK1

1

8

High-throughput

0.734

High

353885

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.724

High

1086475

KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2

1

5

High-throughput

0.691

High

1151611

TRIP6
Thyroid receptor-interacting protein 6

1

9

High-throughput

0.691

High

1383739

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

19

High-throughput

0.691

High

193032

CFLAR
CASP8 and FADD-like apoptosis regulator

1

0

Small-scale

0.687

High

1104640

IKZF1
DNA-binding protein Ikaros

3

2

High-throughput

0.662

High

1383738

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

3

Small-scale

0.657

High

508397

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.647

High

906733

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

10

Small-scale

0.647

High

957808

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

10

High-throughput

0.647

High

982273

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

10

High-throughput

0.647

High

1006608

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.647

High

378158

TNFA
Tumor necrosis factor

3

2

Small-scale

0.640

High

366256

FA9
Coagulation factor IX

2

1

High-throughput

0.628

High

868306

P2RY1
P2Y purinoceptor 1

2

2

High-throughput

0.628

High

1383735

IKZF5
Zinc finger protein Pegasus

2

3

High-throughput

0.628

High

1218740

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

8

High-throughput

0.625

High

955987

RAB8A
Ras-related protein Rab-8A

1

3

Small-scale

0.618

High

1113937

CUL3
Cullin-3

1

14

High-throughput

0.618

High

1383744

NEMO
NF-kappa-B essential modulator

1

12

Small-scale

0.618

High

1109643

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

20

Small-scale

0.611

High

620511

NUCL
Nucleolin

2

4

High-throughput

0.601

High

1310622

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

18

High-throughput

0.584

High

1295522

MIB1
E3 ubiquitin-protein ligase MIB1

1

18

High-throughput

0.575

High

1098531

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

4

Small-scale

0.561

High

1383734

CARD6
Caspase recruitment domain-containing protein 6

1

3

Small-scale

0.553

High

469435

ELNE
Neutrophil elastase

1

1

High-throughput

0.536

High

559447

XRCC5
X-ray repair cross-complementing protein 5

1

2

High-throughput

0.536

High

723252

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

1

High-throughput

0.536

High

876107

TCPE
T-complex protein 1 subunit epsilon

1

5

High-throughput

0.536

High

882079

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.536

High

1007191

TCPB
T-complex protein 1 subunit beta

1

9

High-throughput

0.536

High

1064356

DEMA
Dematin

1

7

High-throughput

0.536

High

1383731

TMM74
Transmembrane protein 74

1

2

High-throughput

0.536

High

1383732

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.536

High

996514

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.527

High

788735

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

923720

PLAT3
Phospholipase A and acyltransferase 3

1

0

High-throughput

0.513

High

1252579

MACC1
Metastasis-associated in colon cancer protein 1

1

0

High-throughput

0.513

High

1275318

PLPR4
Phospholipid phosphatase-related protein type 4

1

0

High-throughput

0.513

High

1341061

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.513

High

1383729

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.513

High

1383743

JAG2
Protein jagged-2

1

20

Small-scale

0.501

High

1383730

LOXL4
Lysyl oxidase homolog 4

1

2

High-throughput

0.489

High

213989

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

11

Small-scale

0.479

High

294137

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

1252170

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1278061

MAVS
Mitochondrial antiviral-signaling protein

1

12

Small-scale

0.479

High

1290344

SERC5
Serine incorporator 5

1

1

Small-scale

0.479

High

1336811

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

11

High-throughput

0.479

High

1383737

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

17

High-throughput

0.479

High

1383742

XPO7
Exportin-7

1

13

High-throughput

0.479

High

1186420

ASTRB
Protein Aster-B

1

2

High-throughput

0.445

High

1383736

AZI2
5-azacytidine-induced protein 2

1

3

High-throughput

0.445

High

1256549

CE128
Centrosomal protein of 128 kDa

1

10

High-throughput

0.437

High

844851

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

1383733

NUP58
Nucleoporin p58/p45

2

0

High-throughput

0.328

High

224513

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

631816

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.279

Low

1249660

CF015
Uncharacterized protein C6orf15

1

0

High-throughput

0.279

Low

1329150

DB125
Beta-defensin 125

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025