HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SH2B2 (Q9JID9)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.671

Property	Details
Experiments	9989826, 11997497, 10854852, 20298671
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 621
+	Hs
		145972 CBL_HUMAN (1-913): 0: 894: 91.05		SH2B2_HUMAN (17-621): 4.8e-157: 467: 79.68
+	Hs
		548639 CBL_HUMAN (1-913): 0: 894: 91.05		VAV_HUMAN (181-602): 1.84e-67: 237: 11.57
+	Mm
		403415 CBL_MOUSE (1-913): 0: 923: 100.00		SRC_MOUSE (283-513): 7.56e-50: 183: 14.74
+	Mm
		610633 CBL_MOUSE (1-913): 0: 923: 100.00		NCK1_MOUSE (163-499): 3.05e-50: 180: 14.45
+	Hs
		610308 CBL_HUMAN (1-913): 0: 894: 91.05		VAV2_HUMAN (181-599): 2.24e-56: 206: 12.67
+	Mm
		610582 CBL_MOUSE (1-913): 0: 923: 100.00		SHC1_MOUSE (299-507): 4.64e-45: 170: 20.85
+	Hs
		208994 CBL_HUMAN (1-913): 0: 894: 91.05		NCK2_HUMAN (163-499): 3.49e-54: 191: 14.89
+	Hs
		454799 CBL_HUMAN (1-913): 0: 894: 91.05		FGR_HUMAN (267-506): 1.26e-49: 182: 16.47
+	Mm
		610604 CBL_MOUSE (1-913): 0: 923: 100.00		PLCG1_MOUSE (393-616): 5.75e-38: 153: 15.18
+	Hs
		557607 CBL_HUMAN (1-913): 0: 894: 91.05		NCK1_HUMAN (163-499): 6.22e-50: 179: 14.16
+	Hs
		561381 CBL_HUMAN (1-913): 0: 894: 91.05		FER_HUMAN (253-512): 1.16e-43: 169: 16.15
+	Hs
		610247 CBL_HUMAN (1-913): 0: 894: 91.05		SHC1_HUMAN (293-507): 2.18e-41: 160: 20.46
+	Hs
		522778 CBL_HUMAN (1-913): 0: 894: 91.05		SRC_HUMAN (283-513): 3.5e-41: 159: 15.87
+	Mm
		610555 CBL_MOUSE (1-913): 0: 923: 100.00		CSK_MOUSE (403-489): 8.79e-30: 124: 29.89
+	Hs
		580928 CBL_HUMAN (1-913): 0: 894: 91.05		PLCG1_HUMAN (393-616): 6.03e-38: 152: 15.18
+	Hs
		610276 CBL_HUMAN (1-913): 0: 894: 91.05		CSK_HUMAN (403-489): 3.67e-29: 122: 28.74
+	Mm
		610566 CBL_MOUSE (1-913): 0: 923: 100.00		KSYK_MOUSE (409-515): 9.62e-16: 82.8: 22.02
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (403-491): 8.49e-16: 78.5: 26.97
+	Hs
		610286 CBL_HUMAN (1-913): 0: 894: 91.05		KSYK_HUMAN (397-515): 3.69e-16: 83.9: 20.66
+	Hs
		610338 CBL_HUMAN (1-913): 0: 894: 91.05		GRB2_HUMAN (403-513): 7.5e-16: 78.9: 25.23